7DDZ
| The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028 | 分子名称: | FLAVIN MONONUCLEOTIDE, Human Neuropeptide Y Y2 Receptor fusion protein, ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | 登録日 | 2020-10-30 | 公開日 | 2021-01-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for ligand recognition of the neuropeptide Y Y 2 receptor. Nat Commun, 12, 2021
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7DDD
| SARS-Cov2 S protein at close state | 分子名称: | Spike glycoprotein | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2020-10-28 | 公開日 | 2020-11-25 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nat Commun, 12, 2021
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7DK7
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7DCX
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1P5T
| Crystal Structure of Dok1 PTB Domain | 分子名称: | Docking protein 1 | 著者 | Shi, N, Ye, S, Liu, Y, Zhou, W, Ding, Y, Lou, Z, Qiang, B, Yuan, J, Rao, Z. | 登録日 | 2003-04-28 | 公開日 | 2004-02-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain J.BIOL.CHEM., 279, 2004
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5WXB
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6DQ4
| LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR GSK-J1 | 分子名称: | 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2018-06-10 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.392 Å) | 主引用文献 | Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J. Med. Chem., 61, 2018
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6DQ9
| Linked KDM5A JMJ Domain Bound to the Covalent Inhibitor N69 i.e. [2-((3-acrylamidophenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid] | 分子名称: | 1,2-ETHANEDIOL, 2-{(R)-[3-(acryloylamino)phenyl][2-(piperidin-1-yl)ethoxy]methyl}thieno[3,2-b]pyridine-7-carboxylic acid, DIMETHYL SULFOXIDE, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2018-06-10 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.748 Å) | 主引用文献 | Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J. Med. Chem., 61, 2018
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6DQD
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5XDM
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6DQ5
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6DQE
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5HGU
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8OWV
| H6 and F2 nanobodies bound to SARS-CoV-2 spike RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F2, GLYCEROL, ... | 著者 | Mikolajek, H, Naismith, J.H, Owens, R.J. | 登録日 | 2023-04-28 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2. Open Biology, 14, 2024
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8OYU
| Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '2 up 1 down' RBD conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ... | 著者 | Weckener, M, Naismith, J.H, Owens, R.J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2. Open Biology, 14, 2024
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8OYT
| Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ... | 著者 | Weckener, M, Naismith, J.H, Owens, R.J. | 登録日 | 2023-05-05 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2. Open Biology, 14, 2024
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8OWT
| SARS-CoV-2 spike RBD with A8 and H3 nanobodies bound | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody A8, ... | 著者 | Mikolajek, H, Naismith, J.H, Owens, R.J. | 登録日 | 2023-04-28 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2. Open Biology, 14, 2024
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8OWW
| B5-5 nanobody bound to SARS-CoV-2 spike RBD (Wuhan) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, B5-5 nanobody, ... | 著者 | Cornish, K.A.S, Naismith, J.H, Owens, R.J. | 登録日 | 2023-04-28 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.969 Å) | 主引用文献 | Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2. Open Biology, 14, 2024
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7WWM
| S protein of Delta variant in complex with ZWC6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2022-02-13 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination. Signal Transduct Target Ther, 7, 2022
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7WWL
| S protein of Delta variant in complex with ZWD12 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2022-02-13 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination. Signal Transduct Target Ther, 7, 2022
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8YY8
| Fzd7 -Gs complex | 分子名称: | Frizzled-7, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, B, Xu, L, Han, G.W, Xu, F. | 登録日 | 2024-04-03 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s . Cell Res., 31, 2021
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8DWB
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6LNK
| Candida albicans Fructose-1,6-bisphosphate aldolase | 分子名称: | 1,2-ETHANEDIOL, Fructose-bisphosphate aldolase, ZINC ION | 著者 | Huang, Y, Cao, H, Ren, Y, Wan, J. | 登録日 | 2019-12-30 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.639 Å) | 主引用文献 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65, 2022
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6B5V
| Structure of TRPV5 in complex with econazole | 分子名称: | 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, Transient receptor potential cation channel subfamily V member 5 | 著者 | Hughes, T.E.T, Lodowski, D.T, Huynh, K.W, Yazici, A, del Rosario, J, Kapoor, A, Basak, S, Samanta, A, Chakrapani, S, Zhou, Z.H, Filizola, M, Rohacs, T, Han, S, Moiseenkova-Bell, V.Y. | 登録日 | 2017-09-29 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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6VN2
| USP7 IN COMPLEX WITH LIGAND COMPOUND 18 | 分子名称: | 1-({7-[(2R)-5-chloro-2-(piperazine-1-carbonyl)-2,3-dihydro-1-benzofuran-7-yl]thieno[3,2-b]pyridin-2-yl}methyl)-1H-pyrrole-2,5-dione, ACETATE ION, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M. | 登録日 | 2020-01-29 | 公開日 | 2020-04-29 | 最終更新日 | 2020-06-17 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020
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