6B5V

Structure of TRPV5 in complex with econazole

Summary for 6B5V

Entry DOI	10.2210/pdb6b5v/pdb
EMDB information	7058
Descriptor	Transient receptor potential cation channel subfamily V member 5, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION (3 entities in total)
Functional Keywords	trpv5, econazole, transient receptor potential channel, cryo-em, membrane protein
Biological source	Oryctolagus cuniculus (Rabbit)
Total number of polymer chains	4
Total formula weight	333165.44
Authors	Hughes, T.E.T.,Lodowski, D.T.,Huynh, K.W.,Yazici, A.,del Rosario, J.,Kapoor, A.,Basak, S.,Samanta, A.,Chakrapani, S.,Zhou, Z.H.,Filizola, M.,Rohacs, T.,Han, S.,Moiseenkova-Bell, V.Y. (deposition date: 2017-09-29, release date: 2017-12-27, Last modification date: 2024-03-13)
Primary citation	Hughes, T.E.T.,Lodowski, D.T.,Huynh, K.W.,Yazici, A.,Del Rosario, J.,Kapoor, A.,Basak, S.,Samanta, A.,Han, X.,Chakrapani, S.,Zhou, Z.H.,Filizola, M.,Rohacs, T.,Han, S.,Moiseenkova-Bell, V.Y. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat. Struct. Mol. Biol., 25:53-60, 2018 Cited by PubMed: 29323279 DOI: 10.1038/s41594-017-0009-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.8 Å)

Structure validation