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CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-18 AKA 7-(3-(2,3-DIHYDRO-1H-INDEN-1-YLAMINO)-1-PHENYLPROPYL)-1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[(1R)-3-{[(1R)-2,3-dihydro-1H-inden-1-yl]amino}-1-phenylpropyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, ...
著者	Khan, J.A.
登録日	2021-01-06
公開日	2021-04-21
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO). Bioorg.Med.Chem.Lett., 42, 2021

6JUI

The atypical Myb-like protein Cdc5 contains two distinct nucleic acid-binding surfaces
分子名称:	Pre-mRNA-splicing factor CEF1
著者	Wang, C, Li, G, Li, M, Yang, J, Liu, J.
登録日	2019-04-14
公開日	2020-02-19
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.402 Å)
主引用文献	Two distinct nucleic acid binding surfaces of Cdc5 regulate development. Biochem.J., 476, 2019

7M2F

CDK2 with compound 14 inhibitor with carboxylate
分子名称:	Cyclin-dependent kinase 2, [(1r,4r)-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl]acetic acid
著者	Longenecker, K.L, Qiu, W, Korepanova, A, Tong, Y.
登録日	2021-03-16
公開日	2021-07-07
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.632 Å)
主引用文献	Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors. Acs Med.Chem.Lett., 12, 2021

5E2V

Anti-TAU AT8 FAB with doubly phosphorylated TAU peptide
分子名称:	AT8 HEAVY CHAIN, AT8 LIGHT CHAIN, GLYCEROL, ...
著者	Malia, T, Teplyakov, A.
登録日	2015-10-01
公開日	2016-02-24
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.64 Å)
主引用文献	Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8. Proteins, 84, 2016

4F3M

Crystal structure of CRISPR-associated protein
分子名称:	1,2-ETHANEDIOL, BH0337 protein, SULFATE ION
著者	Ke, A, Nam, K.H.
登録日	2012-05-09
公開日	2012-08-15
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.71 Å)
主引用文献	Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System. Structure, 20, 2012

7DLV

shrimp dUTPase in complex with Stl
分子名称:	CALCIUM ION, Orf20, SULFATE ION, ...
著者	Ma, Q, Wang, F.
登録日	2020-11-30
公開日	2021-12-01
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.525 Å)
主引用文献	Structural basis of staphylococcal Stl inhibition on a eukaryotic dUTPase. Int.J.Biol.Macromol., 184, 2021

5YJZ

The native crystal structure of Rv3197 from Mycobacterium tuberculosis
分子名称:	GLYCEROL, Probable conserved ATP-binding protein ABC transporter, SULFATE ION
著者	Zhang, Q.Q, Rao, Z.H.
登録日	2017-10-11
公開日	2018-02-07
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.16 Å)
主引用文献	Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018

5E2W

Anti-TAU AT8 FAB with triply phosphorylated TAU peptide
分子名称:	AT8 HEAVY CHAIN, AT8 LIGHT CHAIN, TAU-PHOSPHOPEPTIDE
著者	Malia, T, Teplyakov, A.
登録日	2015-10-01
公開日	2016-02-24
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8. Proteins, 84, 2016

5YK1

The complex structure of Rv3197-AMPPNP from Mycobacterium tuberculosis
分子名称:	GLYCEROL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable conserved ATP-binding protein ABC transporter, ...
著者	Rao, Z.H, Zhang, Q.Q.
登録日	2017-10-11
公開日	2018-02-07
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.103 Å)
主引用文献	Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018

7D3M

FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY R50
分子名称:	O/TIBET/99 VP1, O/TIBET/99 VP2, O/TIBET/99 VP3, ...
著者	He, Y, Lou, Z.
登録日	2020-09-19
公開日	2021-04-14
最終更新日	2021-05-12
実験手法	ELECTRON MICROSCOPY (3.94 Å)
主引用文献	Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization. Plos Pathog., 17, 2021

7D3K

FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY B77
分子名称:	B77 VH, B77 VL, O/TIBET/99 VP1, ...
著者	He, Y, Lou, Z.
登録日	2020-09-19
公開日	2021-04-14
最終更新日	2024-03-27
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization. Plos Pathog., 17, 2021

7D3R

FOOT AND MOUTH DISEASE VIRUS A/WH/CHA/09-BOUND THE SINGLE CHAIN FRAGME ANTIBODY R50
分子名称:	A/WH/CHA/09 VP1, A/WH/CHA/09 VP2, A/WH/CHA/09 VP3, ...
著者	He, Y, Lou, Z.
登録日	2020-09-20
公開日	2021-04-14
最終更新日	2021-05-12
実験手法	ELECTRON MICROSCOPY (3.49 Å)
主引用文献	Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization. Plos Pathog., 17, 2021

7D3L

FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY F145
分子名称:	F145 VH, F145 VL, O/TIBET/99 VP1, ...
著者	He, Y, Lou, Z.
登録日	2020-09-19
公開日	2021-04-14
最終更新日	2021-05-12
実験手法	ELECTRON MICROSCOPY (3.68 Å)
主引用文献	Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization. Plos Pathog., 17, 2021

5YK2

The complex structure of Rv3197-erythromycin from Mycobacterium tuberculosis
分子名称:	ERYTHROMYCIN A, Probable conserved ATP-binding protein ABC transporter
著者	Rao, Z.H, Zhang, Q.Q.
登録日	2017-10-11
公開日	2018-02-07
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.807 Å)
主引用文献	Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018

5YK0

The complex structure of Rv3197-ADP from Mycobacterium tuberculosis
分子名称:	ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Probable conserved ATP-binding protein ABC transporter, ...
著者	Rao, Z.H, Zhang, Q.Q.
登録日	2017-10-11
公開日	2018-02-07
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.102 Å)
主引用文献	Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018

4JPE

Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
分子名称:	(4R)-2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one, Beta-secretase 1, NICKEL (II) ION
著者	Vigers, G.P.A, Smith, D.
登録日	2013-03-19
公開日	2013-04-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species. J.Med.Chem., 56, 2013

4JOO

Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
分子名称:	(4R)-2'-amino-6-bromo-1',2,2-trimethyl-2,3-dihydrospiro[chromene-4,4'-imidazol]-5'(1'H)-one, Beta-secretase 1, NICKEL (II) ION
著者	Vigers, G.P.A, Smith, D.
登録日	2013-03-18
公開日	2013-04-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species. J.Med.Chem., 56, 2013

4JG4

Ligand concentration regulates the pathways of coupled protein folding and binding
分子名称:	PYROPHOSPHATE, Ribonuclease P protein component
著者	Tonthat, N.K.
登録日	2013-02-28
公開日	2014-01-22
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.296 Å)
主引用文献	Ligand concentration regulates the pathways of coupled protein folding and binding. J.Am.Chem.Soc., 136, 2014

5E2T

Crystal structure of anti-TAU antibody AT8 FAB
分子名称:	AT8 HEAVY CHAIN, AT8 LIGHT CHAIN, CALCIUM ION
著者	Malia, T, Teplyakov, A.
登録日	2015-10-01
公開日	2016-02-24
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8. Proteins, 84, 2016

4MGV

Crystal structure of FK506 binding domain of plasmodium VIVAX FKBP35 In complex with inhibitor D5
分子名称:	70 kDa peptidylprolyl isomerase, putative, N'-(1-adamantylcarbonyl)pyridine-4-carbohydrazide
著者	Rajan, S, Harikishore, A, Yoon, H.S.
登録日	2013-08-29
公開日	2013-12-04
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.72 Å)
主引用文献	Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. Acs Med.Chem.Lett., 4, 2013

2OKR

Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer
分子名称:	MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14
著者	Ter Haar, E.
登録日	2007-01-17
公開日	2007-02-06
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Crystal structure of the P38alpha-MAPKAP kinase 2 heterodimer. J.Biol.Chem., 282, 2007

2OH0

Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors
分子名称:	(2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE, Inhibitory peptide, cAMP-dependent protein kinase, ...
著者	Stoll, V.S.
登録日	2007-01-09
公開日	2007-03-20
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt. Bioorg.Med.Chem., 15, 2007

5H43

Structural and mechanistical studies of the nuclear import by Importin-alpha
分子名称:	Histone acetyltransferase KAT8, Importin subunit alpha-1
著者	Wang, R, Li, Y.
登録日	2016-10-28
公開日	2017-10-25
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1 Traffic, 19, 2018

7XE4

structure of a membrane-bound glycosyltransferase
分子名称:	(11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J.
登録日	2022-03-29
公開日	2023-03-29
最終更新日	2023-04-19
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1. Nature, 616, 2023

5HMO

myosin X motor activity
分子名称:	Unconventional myosin-X
著者	Ropars, V, Blanc, F, Samazan, F, Houdusse, A.
登録日	2016-01-16
公開日	2016-09-07
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (3.493 Å)
主引用文献	The myosin X motor is optimized for movement on actin bundles. Nat Commun, 7, 2016

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表示件数:	25
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