7LAL

CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-18 AKA 7-(3-(2,3-DIHYDRO-1H-INDEN-1-YLAMINO)-1-PHENYLPROPYL)-1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE

Summary for 7LAL

Entry DOI	10.2210/pdb7lal/pdb
Descriptor	Myeloperoxidase light chain, 7-[(1R)-3-{[(1R)-2,3-dihydro-1H-inden-1-yl]amino}-1-phenylpropyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, Isoform H14 of Myeloperoxidase, ... (11 entities in total)
Functional Keywords	myeloperoxidase, oxidoreductase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	135392.29
Authors	Khan, J.A. (deposition date: 2021-01-06, release date: 2021-04-21, Last modification date: 2023-10-18)
Primary citation	Hu, C.H.,Neissel Valente, M.W.,Halpern, O.S.,Jusuf, S.,Khan, J.A.,Locke, G.A.,Duke, G.J.,Liu, X.,Duclos, F.J.,Wexler, R.R.,Kick, E.K.,Smallheer, J.M. Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO). Bioorg.Med.Chem.Lett., 42:128010-128010, 2021 Cited by PubMed: 33811992 DOI: 10.1016/j.bmcl.2021.128010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation