5YYZ
| Crystal structure of the MEK1 FHA domain in complex with the HOP1 pThr318 peptide. | 分子名称: | Meiosis-specific protein HOP1, Meiosis-specific serine/threonine-protein kinase MEK1 | 著者 | Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y. | 登録日 | 2017-12-11 | 公開日 | 2018-10-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Structural insights into the recognition of phosphorylated Hop1 by Mek1 Acta Crystallogr D Struct Biol, 74, 2018
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5YYX
| Crystal Structure of the MEK1 FHA domain | 分子名称: | Meiosis-specific serine/threonine-protein kinase MEK1 | 著者 | Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y. | 登録日 | 2017-12-11 | 公開日 | 2018-10-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.684 Å) | 主引用文献 | Structural insights into the recognition of phosphorylated Hop1 by Mek1 Acta Crystallogr D Struct Biol, 74, 2018
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3H3B
| Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain | 分子名称: | Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 | 著者 | Zhou, H, Liu, Y, Niu, L, Zhu, J, Teng, M. | 登録日 | 2009-04-16 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21. J.Biol.Chem., 286, 2011
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5TKB
| CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND | 分子名称: | ETHANOL, MAGNESIUM ION, N-[(2R)-2,3-dihydroxy-2-methylpropyl]-8-(methylamino)-6-[(2,3,5,6-tetrafluorophenyl)amino]imidazo[1,2-b]pyridazine-3-carboxamide, ... | 著者 | Sack, J.S. | 登録日 | 2016-10-06 | 公開日 | 2016-12-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm, 8, 2017
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5TKD
| CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE | 分子名称: | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION | 著者 | Muckelbauer, J.K. | 登録日 | 2016-10-06 | 公開日 | 2016-12-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm, 8, 2017
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4XHQ
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4X9H
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5GON
| Structures of a beta-lactam bridged analogue in complex with tubulin | 分子名称: | (3R,4R)-4-(4-methoxy-3-oxidanyl-phenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Zhou, L, Liu, Y, Cheng, L, Wang, Y. | 登録日 | 2016-07-28 | 公開日 | 2017-03-22 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin. J. Med. Chem., 59, 2016
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5CIR
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3I97
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6FMF
| Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid | 著者 | Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P. | 登録日 | 2018-01-31 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.811 Å) | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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6FMC
| Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1 | 著者 | Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P. | 登録日 | 2018-01-30 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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5DMJ
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5DMI
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4NWM
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8K37
| Structure of the bacteriophage lambda neck | 分子名称: | Head-tail connector protein FII, Tail tube protein, Tail tube terminator protein | 著者 | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | 登録日 | 2023-07-14 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8K39
| Structure of the bacteriophage lambda portal vertex | 分子名称: | Major capsid protein, Portal protein B | 著者 | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | 登録日 | 2023-07-14 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8K38
| The structure of bacteriophage lambda portal-adaptor | 分子名称: | Head completion protein, Portal protein B | 著者 | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | 登録日 | 2023-07-14 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8K36
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8K35
| Structure of the bacteriophage lambda tail tip complex | 分子名称: | IRON/SULFUR CLUSTER, Tail tip assembly protein I, Tail tip protein L, ... | 著者 | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | 登録日 | 2023-07-14 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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3QWQ
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3QWR
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7K7O
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7K7Q
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6JOY
| The X-ray Crystallographic Structure of Branching Enzyme from Rhodothermus obamensis STB05 | 分子名称: | 1,4-alpha-glucan branching enzyme GlgB | 著者 | Li, Z.F, Ban, X.F, Jiang, H.M, Wang, Z, Jin, T.C, Li, C.M, Gu, Z.B. | 登録日 | 2019-03-25 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.392 Å) | 主引用文献 | Flexible Loop in Carbohydrate-Binding Module 48 Allosterically Modulates Substrate Binding of the 1,4-alpha-Glucan Branching Enzyme. J.Agric.Food Chem., 69, 2021
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