3QWR

Crystal structure of IL-23 in complex with an adnectin

Summary for 3QWR

• Entry DOI: 10.2210/pdb3qwr/pdb
• Related: 3QWQ
• Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ADNECTIN, ... (5 entities in total)
• Functional Keywords: four-helix bundle cytokine, ig domain, glycoprotein, immunoglobulin domain, secreted, antiviral defense, immune response, inflammatory response, innate immunity, tissue remodeling, adnectin, engineered binding protein, antibody mimic, protein binding-cytokine complex, protein binding/cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 66664.54

Authors

Wei, A.,Sheriff, S. (deposition date: 2011-02-28, release date: 2012-02-01, Last modification date: 2023-09-13)

• Primary citation: Ramamurthy, V.,Krystek, S.R.,Bush, A.,Wei, A.,Emanuel, S.L.,Das Gupta, R.,Janjua, A.,Cheng, L.,Murdock, M.,Abramczyk, B.,Cohen, D.,Lin, Z.,Morin, P.,Davis, J.H.,Dabritz, M.,McLaughlin, D.C.,Russo, K.A.,Chao, G.,Wright, M.C.,Jenny, V.A.,Engle, L.J.,Furfine, E.,Sheriff, S.; Structures of adnectin/protein complexes reveal an expanded binding footprint.; Structure, 20:259-269, 2012; PubMed: 22325775; DOI: 10.1016/j.str.2011.11.016

Experimental method

X-RAY DIFFRACTION (3.25 Å)