3QWQ

Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin

Summary for 3QWQ

• Entry DOI: 10.2210/pdb3qwq/pdb
• Related: 3QWR
• Descriptor: Epidermal growth factor receptor, ADNECTIN, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: cell surface receptor, tyrosine kinase, glycoprotein, adnectin, antitumor, drug, engineered binding protein, antibody mimic, signaling protein, protein binding-signaling protein complex, protein binding/signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 87637.55

Authors

Sheriff, S. (deposition date: 2011-02-28, release date: 2012-02-01, Last modification date: 2023-09-13)

• Primary citation: Ramamurthy, V.,Krystek, S.R.,Bush, A.,Wei, A.,Emanuel, S.L.,Das Gupta, R.,Janjua, A.,Cheng, L.,Murdock, M.,Abramczyk, B.,Cohen, D.,Lin, Z.,Morin, P.,Davis, J.H.,Dabritz, M.,McLaughlin, D.C.,Russo, K.A.,Chao, G.,Wright, M.C.,Jenny, V.A.,Engle, L.J.,Furfine, E.,Sheriff, S.; Structures of adnectin/protein complexes reveal an expanded binding footprint.; Structure, 20:259-269, 2012; PubMed: 22325775; DOI: 10.1016/j.str.2011.11.016

Experimental method

X-RAY DIFFRACTION (2.75 Å)