3QWQ

Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Epidermal growth factor receptor	polymer	648	71465.5	1	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (human)	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
2	B (B)	ADNECTIN	polymer	114	12604.8	1		Homo sapiens (human)
3	C, F (C, F)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1057.0	2	In PDB GlyTouCan (G82348BZ)
4	D (D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	E (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	G, H (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	I, J (A, B)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: -23 - 618 (UniProt: P00533)

PDB	External Database	Details
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag
His 624	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84070.3
Branched	Number of molecules	4
	Total formula weight	3124.9
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	87637.6

*Water molecules are not included.