3QWR

Crystal structure of IL-23 in complex with an adnectin

Summary for 3QWR
Related3QWQ
DescriptorInterleukin-12 subunit beta, Interleukin-23 subunit alpha, ADNECTIN, ... (5 entities in total)
Functional Keywordsfour-helix bundle cytokine, ig domain, glycoprotein, immunoglobulin domain, secreted, antiviral defense, immune response, inflammatory response, innate immunity, tissue remodeling, adnectin, engineered binding protein, antibody mimic, protein binding-cytokine complex, protein binding/cytokine
Biological sourceHomo sapiens (human)
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Total number of polymer chains3
Total formula weight66664.54
Authors
Wei, A.,Sheriff, S. (deposition date: 2011-02-28, release date: 2012-02-01, Last modification date: 2020-07-29)
Primary citationAbramczyk, B.,Bush, A.,Chao, G.,Cheng, L.,Cohen, D.,Dabritz, M.,Das Gupta, R.,Davis, J.H.,Emanuel, S.L.,Engle, L.J.,Furfine, E.,Janjua, A.,Jenny, V.A.,Krystek, S.R.,Lin, Z.,McLaughlin, D.C.,Morin, P.,Murdock, M.,Ramamurthy, V.,Russo, K.A.,Sheriff, S.,Wei, A.,Wright, M.C.
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Structure, 20:259-269, 2012
PubMed: 22325775
DOI: 110.1016/j.str.2011.11.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.25 Å)
Structure validation
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PDB entries from 2021-06-09