5TKB

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND

Summary for 5TKB

• Entry DOI: 10.2210/pdb5tkb/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: phosphodiesterase, pde4d, alternative splicing, camp, cytoplasm, cytoskeleton, hydrolase, membrane, metal- binding, phosphoprotein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 177945.73

Authors

Sack, J.S. (deposition date: 2016-10-06, release date: 2016-12-28, Last modification date: 2023-10-04)

• Primary citation: Moslin, R.,Gardner, D.,Santella, J.,Zhang, Y.,Duncia, J.V.,Liu, C.,Lin, J.,Tokarski, J.S.,Strnad, J.,Pedicord, D.,Chen, J.,Blat, Y.,Zupa-Fernandez, A.,Cheng, L.,Sun, H.,Chaudhry, C.,Huang, C.,D'Arienzo, C.,Sack, J.S.,Muckelbauer, J.K.,Chang, C.,Tredup, J.,Xie, D.,Aranibar, N.,Burke, J.R.,Carter, P.H.,Weinstein, D.S.; Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.; Medchemcomm, 8:700-712, 2017; PubMed: 30108788; DOI: 10.1039/c6md00560h

Experimental method

X-RAY DIFFRACTION (2.16 Å)