5TKB
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 381 | 43790.2 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | E, L, S, X (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, M, T, Y (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, N, U (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | H, I, J, O, P... (A, B, C, D) | ETHANOL | non-polymer | 46.1 | 8 | Chemie (EOH) | |||
| 6 | AA, K, R, W (D, A, B, C) | N-[(2R)-2,3-dihydroxy-2-methylpropyl]-8-(methylamino)-6-[(2,3,5,6-tetrafluorophenyl)amino]imidazo[1,2-b]pyridazine-3-carboxamide | non-polymer | 442.4 | 4 | Chemie (7DJ) | |||
| 7 | BA, CA, DA, EA (A, B, C, D) | water | water | 18.0 | 471 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 244 - 617 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Met 243 | - | initiating methionine |
| Ala 579 | Ser 715 | engineered mutation |
| Ala 581 | Ser 717 | engineered mutation |
| His 618 | - | expression tag |
| His 619 | - | expression tag |
| His 620 | - | expression tag |
| His 621 | - | expression tag |
| His 622 | - | expression tag |
| His 623 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 175160.7 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2785.1 | |
| All* | Total formula weight | 177945.7 |
