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3I97

B1 domain of human Neuropilin-1 bound with small molecule EG00229

Summary for 3I97
Entry DOI10.2210/pdb3i97/pdb
DescriptorNeuropilin-1, (S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid, GLYCEROL, ... (4 entities in total)
Functional Keywordsneuropilin-1, drug, vegf, angiogenesis, neuropilin, alternative splicing, cell membrane, developmental protein, differentiation, disulfide bond, glycoprotein, heparan sulfate, membrane, neurogenesis, phosphoprotein, polymorphism, proteoglycan, receptor, secreted, transmembrane, membrane protein, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: O14786
Total number of polymer chains2
Total formula weight36921.82
Authors
Allerston, C.K.,Djordjevic, S. (deposition date: 2009-07-10, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citationJarvis, A.,Allerston, C.K.,Jia, H.,Herzog, B.,Garza-Garcia, A.,Winfield, N.,Ellard, K.,Aqil, R.,Lynch, R.,Chapman, C.,Hartzoulakis, B.,Nally, J.,Stewart, M.,Cheng, L.,Menon, M.,Tickner, M.,Djordjevic, S.,Driscoll, P.C.,Zachary, I.,Selwood, D.L.
Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
J.Med.Chem., 53:2215-2226, 2010
Cited by
PubMed: 20151671
DOI: 10.1021/jm901755g
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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