5TKD

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE

Summary for 5TKD

• Entry DOI: 10.2210/pdb5tkd/pdb
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, tyk2, pseudokinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67538.56

Authors

Muckelbauer, J.K. (deposition date: 2016-10-06, release date: 2016-12-28, Last modification date: 2023-10-04)

• Primary citation: Moslin, R.,Gardner, D.,Santella, J.,Zhang, Y.,Duncia, J.V.,Liu, C.,Lin, J.,Tokarski, J.S.,Strnad, J.,Pedicord, D.,Chen, J.,Blat, Y.,Zupa-Fernandez, A.,Cheng, L.,Sun, H.,Chaudhry, C.,Huang, C.,D'Arienzo, C.,Sack, J.S.,Muckelbauer, J.K.,Chang, C.,Tredup, J.,Xie, D.,Aranibar, N.,Burke, J.R.,Carter, P.H.,Weinstein, D.S.; Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.; Medchemcomm, 8:700-712, 2017; PubMed: 30108788; DOI: 10.1039/c6md00560h

Experimental method

X-RAY DIFFRACTION (1.92 Å)