5TKD
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 298 | 33314.8 | 2 | UniProt (P29597) Pfam (PF07714) | Homo sapiens (Human) | |
| 2 | C, E (A, B) | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | non-polymer | 310.4 | 2 | Chemie (7GL) | |||
| 3 | D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A, B: 575 - 869 (UniProt: P29597)
| PDB | External Database | Details |
|---|---|---|
| Gly 572 | - | expression tag |
| His 573 | - | expression tag |
| Met 574 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66629.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 908.9 | |
| All* | Total formula weight | 67538.6 |
