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Crystal structure of Nit6803
分子名称:	Nitrilase
著者	Yuan, Y.A, Yin, B, Wang, C.
登録日	2014-05-09
公開日	2014-12-31
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Structural insights into enzymatic activity and substrate specificity determination by a single amino acid in nitrilase from Syechocystis sp. PCC6803 J.Struct.Biol., 188, 2014

5CHL

Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex
分子名称:	Histone H2A.Z, Vacuolar protein sorting-associated protein 72 homolog
著者	Shan, S, Liang, X, Pan, L, Wu, C, Zhou, Z.
登録日	2015-07-10
公開日	2016-03-09
最終更新日	2017-09-27
実験手法	X-RAY DIFFRACTION (1.892 Å)
主引用文献	Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1 Nat.Struct.Mol.Biol., 23, 2016

7YP1

Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement)
分子名称:	10E4 heavy chain, 10E4 light chain, EBV gH, ...
著者	Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N.
登録日	2022-08-02
公開日	2024-01-31
実験手法	ELECTRON MICROSCOPY (3.54 Å)
主引用文献	Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023

7YOY

Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement)
分子名称:	3E8 heavy chain, 3E8 light chain, 5E3 heavy chain, ...
著者	Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N.
登録日	2022-08-02
公開日	2024-01-31
実験手法	ELECTRON MICROSCOPY (3.64 Å)
主引用文献	Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023

7YP2

Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement)
分子名称:	6H2 heavy chain, 6H2 light chain, Envelope glycoprotein H
著者	Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N.
登録日	2022-08-02
公開日	2024-01-31
実験手法	ELECTRON MICROSCOPY (3.52 Å)
主引用文献	Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023

4GE6

Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7
分子名称:	N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9
著者	Zhang, Z.-Y, Liu, S, Zhang, S.
登録日	2012-08-01
公開日	2012-10-31
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012

4GE5

Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
分子名称:	N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者	Zhang, Z.-Y, Liu, S, Zhang, S.
登録日	2012-08-01
公開日	2012-10-31
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012

4GE2

Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3
分子名称:	N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者	Zhang, Z.-Y, Liu, S, Zhang, S.
登録日	2012-08-01
公開日	2012-10-31
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012

6JJI

Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4 (1:1)
分子名称:	(1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, POTASSIUM ION, RNA (5'-R(GPGPCPUPCPGPGPCPGPGPCPGPGPA)-3')
著者	Zhang, Y.S, Parkinson, G.N, Wei, D.G.
登録日	2019-02-25
公開日	2020-02-26
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Res., 48, 2020

6JJH

Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4
分子名称:	(1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, POTASSIUM ION, RNA (5'-R(GPGPCPUPCPGPGPCPGPGPCPGPGPA)-3')
著者	Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G.
登録日	2019-02-25
公開日	2020-02-26
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (1.74 Å)
主引用文献	Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Res., 48, 2020

6JJF

Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex
分子名称:	COBALT HEXAMMINE(III), DNA (5'-D(GPGPCPTPCPGPGPCPGPGPCPGPGPA)-3'), POTASSIUM ION, ...
著者	Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G.
登録日	2019-02-25
公開日	2020-02-26
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (1.47 Å)
主引用文献	Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Res., 48, 2020

5XXY

Crystal structure of PD-L1 complexed with atezolizumab fab at 2.9A
分子名称:	Programmed cell death 1 ligand 1, heavy chain of atezolizumab fab, light chain of atezolizumab fab
著者	Zhou, A, Zhang, F.
登録日	2017-07-05
公開日	2017-09-20
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab. Oncotarget, 8, 2017

2P4L

Structure and sodium channel activity of an excitatory I1-superfamily conotoxin
分子名称:	I-superfamily conotoxin r11a
著者	Buczek, O, Wei, D.X, Babon, J.J, Yang, X.D, Fiedler, B, Yoshikami, D, Olivera, B.M, Bulaj, G, Norton, R.S.
登録日	2007-03-12
公開日	2007-09-25
最終更新日	2022-03-16
実験手法	SOLUTION NMR
主引用文献	Structure and Sodium Channel Activity of an Excitatory I(1)-Superfamily Conotoxin Biochemistry, 46, 2007

3CTJ

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
分子名称:	2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide, Hepatocyte growth factor receptor
著者	Sack, J.
登録日	2008-04-14
公開日	2008-06-10
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors Bioorg.Med.Chem.Lett., 18, 2008

3F82

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
分子名称:	N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, hepatocyte growth factor receptor
著者	Sack, J.
登録日	2008-11-11
公開日	2009-03-31
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily J.Med.Chem., 52, 2009

3CTH

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
分子名称:	Hepatocyte growth factor receptor, N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
著者	Sack, J.
登録日	2008-04-14
公開日	2008-06-10
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors Bioorg.Med.Chem.Lett., 18, 2008

7DFG

Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir
分子名称:	6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, MAGNESIUM ION, Non-structural protein 7, ...
著者	Li, Z, Zhou, Z, Yu, X.
登録日	2020-11-08
公開日	2021-11-17
最終更新日	2024-05-29
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Structural basis for repurpose and design of nucleotide drugs for treating COVID-19 To Be Published

7DFH

Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin
分子名称:	MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
著者	Li, Z, Zhou, Z, Yu, X.
登録日	2020-11-08
公開日	2021-11-17
最終更新日	2024-05-29
実験手法	ELECTRON MICROSCOPY (2.97 Å)
主引用文献	Structural basis for repurpose and design of nucleotide drugs for treating COVID-19 To Be Published

7DOK

Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir
分子名称:	MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
著者	Li, Z, Yu, X.
登録日	2020-12-14
公開日	2021-12-15
最終更新日	2024-06-05
実験手法	ELECTRON MICROSCOPY (2.73 Å)
主引用文献	Structural basis for repurpose and design of nucleotide drugs for treating COVID-19 To Be Published

7DOI

Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir.
分子名称:	MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
著者	Li, Z, Yu, X.
登録日	2020-12-14
公開日	2021-12-15
最終更新日	2024-06-05
実験手法	ELECTRON MICROSCOPY (2.6 Å)
主引用文献	Structural basis for repurpose and design of nucleotide drugs for treating COVID-19 To Be Published

1WKO

Terminal flower 1 (tfl1) from arabidopsis thaliana
分子名称:	TERMINAL FLOWER 1 protein
著者	Miller, D, Banfield, M.J, Winter, V.J, Brady, R.L.
登録日	2004-06-01
公開日	2005-06-28
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	A divergent external loop confers antagonistic activity on floral regulators FT and TFL1. Embo J., 25, 2006

8DY6

Vaccine elicited Antibody MU89+S27Y bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Stalls, V, Acharya, P.
登録日	2022-08-03
公開日	2023-04-19
最終更新日	2024-05-22
実験手法	ELECTRON MICROSCOPY (4.32 Å)
主引用文献	Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction. Cell Host Microbe, 32, 2024

8DTO

Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Stalls, V, Acharya, P.
登録日	2022-07-26
公開日	2023-04-19
最終更新日	2024-05-22
実験手法	ELECTRON MICROSCOPY (3.57 Å)
主引用文献	Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction. Cell Host Microbe, 32, 2024

8Q8J

Crystal structure of human GPX4-R152H
分子名称:	Glutathione peroxidase
著者	Napolitano, V, Mourao, A, Kolonko, M, Bostock, M.J, Sattler, M, Conrad, M, Popowicz, G.
登録日	2023-08-18
公開日	2024-08-28
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Crystal structure of human GPX4-R152H To Be Published

8Q8N

Crystal structure of human GPX4-U46C-I129S-L130S
分子名称:	Phospholipid hydroperoxide glutathione peroxidase
著者	Bostock, M.J, Mourao, A, Napolitano, V, Sattler, M, Conrad, M, Popowicz, G.
登録日	2023-08-18
公開日	2024-08-28
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	An ultra-rare variant of GPX4 reveals the structural basis to avert neurodegeneration To Be Published

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