Structure and sodium channel activity of an excitatory I1-superfamily conotoxin

Summary for 2P4L

DescriptorI-superfamily conotoxin r11a (1 entity in total)
Functional Keywordsiaa, iodoacetic acid; ina, sodium current; nem, n-ethylmaleimide; nmr, nuclear magnetic resonance; noe, nuclear overhauser effect; tfa, trifluoroacetic acid; vgsc, voltage-gated sodium channel., toxin
Biological sourceConus radiatus
Cellular locationSecreted Q7Z094
Total number of polymer chains1
Total molecular weight4987.67
Buczek, O.,Wei, D.X.,Babon, J.J.,Yang, X.D.,Fiedler, B.,Yoshikami, D.,Olivera, B.M.,Bulaj, G.,Norton, R.S. (deposition date: 2007-03-12, release date: 2007-09-25, Last modification date: 2011-07-13)
Primary citation
Buczek, O.,Wei, D.,Babon, J.J.,Yang, X.,Fiedler, B.,Chen, P.,Yoshikami, D.,Olivera, B.M.,Bulaj, G.,Norton, R.S.
Structure and Sodium Channel Activity of an Excitatory I(1)-Superfamily Conotoxin
Biochemistry, 46:9929-9940, 2007
PubMed: 17696362 (PDB entries with the same primary citation)
DOI: 10.1021/bi700797f
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers34 3.2% 32.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-10-28