2P4L

Structure and sodium channel activity of an excitatory I1-superfamily conotoxin

Summary for 2P4L

DescriptorI-superfamily conotoxin r11a (1 entity in total)
Functional Keywordsiaa, iodoacetic acid; ina, sodium current; nem, n-ethylmaleimide; nmr, nuclear magnetic resonance; noe, nuclear overhauser effect; tfa, trifluoroacetic acid; vgsc, voltage-gated sodium channel., toxin
Biological sourceConus radiatus
Cellular locationSecreted Q7Z094
Total number of polymer chains1
Total molecular weight4987.67
Authors
Buczek, O.,Wei, D.X.,Babon, J.J.,Yang, X.D.,Fiedler, B.,Yoshikami, D.,Olivera, B.M.,Bulaj, G.,Norton, R.S. (deposition date: 2007-03-12, release date: 2007-09-25, Last modification date: 2011-07-13)
Primary citation
Buczek, O.,Wei, D.,Babon, J.J.,Yang, X.,Fiedler, B.,Chen, P.,Yoshikami, D.,Olivera, B.M.,Bulaj, G.,Norton, R.S.
Structure and Sodium Channel Activity of an Excitatory I(1)-Superfamily Conotoxin
Biochemistry, 46:9929-9940, 2007
PubMed: 17696362 (PDB entries with the same primary citation)
DOI: 10.1021/bi700797f
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers343.2%32.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures