3CTJ

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor

Summary for 3CTJ

Entry DOI	10.2210/pdb3ctj/pdb
Related	3C1X 3CTH 3CTK
Descriptor	Hepatocyte growth factor receptor, 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide (3 entities in total)
Functional Keywords	receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P08581
Total number of polymer chains	1
Total formula weight	35857.42
Authors	Sack, J. (deposition date: 2008-04-14, release date: 2008-06-10, Last modification date: 2024-02-21)
Primary citation	Cai, Z.-W.,Wei, D.,Schroeder, G.M.,Cornelius, L.A.,Kim, K.,Chen, X.-T.,Schmidt, R.J.,Williams, D.K.,Tokarski, J.S.,An, Y.,Sack, J.S.,Manne, V.,Kamath, A.,Zhang, Y.,Marathe, P.,Hunt, J.T.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M. Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors Bioorg.Med.Chem.Lett., 18:3224-3229, 2008 Cited by PubMed: 18479916 DOI: 10.1016/j.bmcl.2008.04.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation