3CTJ
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor receptor | polymer | 314 | 35435.0 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF RECEPTOR, SCATTER FACTOR RECEPTOR, SF RECEPTOR, HGF/SF RECEPTOR, MET PROTO-ONCOGENE TYROSINE KINASE, C-MET |
2 | A | 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide | non-polymer | 422.4 | 1 | Chemie (320) | |||
3 | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Gly 1047 | - | expression tag |
Ala 1048 | - | expression tag |
Phe 1194 | Tyr 1194 | engineered mutation |
Phe 1234 | Tyr 1234 | engineered mutation |
Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35435.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 422.4 | |
All* | Total formula weight | 35857.4 |