3CTH
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
Summary for 3CTH
Entry DOI | 10.2210/pdb3cth/pdb |
Related | 3C1X 3CTJ 3CTK |
Descriptor | Hepatocyte growth factor receptor, N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35833.39 |
Authors | Sack, J. (deposition date: 2008-04-14, release date: 2008-06-10, Last modification date: 2024-02-21) |
Primary citation | Cai, Z.-W.,Wei, D.,Schroeder, G.M.,Cornelius, L.A.,Kim, K.,Chen, X.-T.,Schmidt, R.J.,Williams, D.K.,Tokarski, J.S.,An, Y.,Sack, J.S.,Manne, V.,Kamath, A.,Zhang, Y.,Marathe, P.,Hunt, J.T.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M. Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors Bioorg.Med.Chem.Lett., 18:3224-3229, 2008 Cited by PubMed: 18479916DOI: 10.1016/j.bmcl.2008.04.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report