8DTO

Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer

Summary for 8DTO

• Entry DOI: 10.2210/pdb8dto/pdb
• EMDB information: 27706
• Descriptor: CH848.3.D0949.10.17chim.6R.DS.SOSIP.664_N133D_N138T gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hiv-1 envelope, vaccine-induced antibody, broadly neutralizing antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 317743.39

Authors

Stalls, V.,Acharya, P. (deposition date: 2022-07-26, release date: 2023-04-19, Last modification date: 2024-05-22)

• Primary citation: Wiehe, K.,Saunders, K.O.,Stalls, V.,Cain, D.W.,Venkatayogi, S.,Martin Beem, J.S.,Berry, M.,Evangelous, T.,Henderson, R.,Hora, B.,Xia, S.M.,Jiang, C.,Newman, A.,Bowman, C.,Lu, X.,Bryan, M.E.,Bal, J.,Sanzone, A.,Chen, H.,Eaton, A.,Tomai, M.A.,Fox, C.B.,Tam, Y.K.,Barbosa, C.,Bonsignori, M.,Muramatsu, H.,Alam, S.M.,Montefiori, D.C.,Williams, W.B.,Pardi, N.,Tian, M.,Weissman, D.,Alt, F.W.,Acharya, P.,Haynes, B.F.; Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.; Cell Host Microbe, 32:693-709.e7, 2024; PubMed: 38670093; DOI: 10.1016/j.chom.2024.04.006

Experimental method

ELECTRON MICROSCOPY (3.57 Å)