3F82

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Summary for 3F82

• Entry DOI: 10.2210/pdb3f82/pdb
• Descriptor: hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (3 entities in total)
• Functional Keywords: alternative splicing, receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P08581
• Total number of polymer chains: 1
• Total formula weight: 35947.92

Authors

Sack, J. (deposition date: 2008-11-11, release date: 2009-03-31, Last modification date: 2024-04-03)

• Primary citation: Schroeder, G.M.,An, Y.,Cai, Z.W.,Chen, X.T.,Clark, C.,Cornelius, L.A.,Dai, J.,Gullo-Brown, J.,Gupta, A.,Henley, B.,Hunt, J.T.,Jeyaseelan, R.,Kamath, A.,Kim, K.,Lippy, J.,Lombardo, L.J.,Manne, V.,Oppenheimer, S.,Sack, J.S.,Schmidt, R.J.,Shen, G.,Stefanski, K.,Tokarski, J.S.,Trainor, G.L.,Wautlet, B.S.,Wei, D.,Williams, D.K.,Zhang, Y.,Zhang, Y.,Fargnoli, J.,Borzilleri, R.M.; Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily; J.Med.Chem., 52:1251-1254, 2009; PubMed: 19260711; DOI: 10.1021/jm801586s

Experimental method

X-RAY DIFFRACTION (2.5 Å)