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5D3V
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BU of 5d3v by Molmil
Crystal Structure of the P-Rex1 PH domain with Citrate Bound
分子名称: CITRATE ANION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3X
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BU of 5d3x by Molmil
Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3Y
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BU of 5d3y by Molmil
Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3W
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BU of 5d3w by Molmil
Crystal Structure of the P-Rex1 PH domain with Sulfate Bound
分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, SULFATE ION
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D27
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BU of 5d27 by Molmil
Crystal Structure of the P-Rex1 PH domain
分子名称: NICKEL (II) ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-05
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5DO9
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BU of 5do9 by Molmil
Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q
分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ...
著者Taylor, V.G, Tesmer, J.J.G.
登録日2015-09-10
公開日2016-01-20
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the Regulator of G Protein Signaling 8 (RGS8)-G alpha q Complex: MOLECULAR BASIS FOR G alpha SELECTIVITY.
J.Biol.Chem., 291, 2016
5FI0
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BU of 5fi0 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1
分子名称: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-12-22
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.282 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
3PUH
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BU of 3puh by Molmil
Cocaine Esterase, wild-type biologically active dimer
分子名称: Cocaine esterase, GLYCEROL, SULFATE ION
著者Nance, M.R, Tesmer, J.J.G.
登録日2010-12-04
公開日2011-09-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3PUI
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BU of 3pui by Molmil
Cocaine Esterase with mutations G4C, S10C
分子名称: CHLORIDE ION, Cocaine esterase, SODIUM ION
著者Nance, M.R, Tesmer, J.J.G.
登録日2010-12-04
公開日2011-09-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3QC9
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BU of 3qc9 by Molmil
Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg
分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Huang, C.-C, Tesmer, J.J.G.
登録日2011-01-15
公開日2011-02-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain.
Biochemistry, 50, 2011
6ABP
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BU of 6abp by Molmil
SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-L-arabinopyranose, beta-L-arabinopyranose
著者Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
登録日1991-04-25
公開日1991-10-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
5UKM
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BU of 5ukm by Molmil
bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)
分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cruz-Rodriguez, O, Tesmer, J.J.G.
登録日2017-01-23
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
5UKK
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BU of 5ukk by Molmil
Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak)
分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cato, M.C, Homan, K.T, Tesmer, J.J.G.
登録日2017-01-23
公開日2017-04-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
5UKL
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BU of 5ukl by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
分子名称: 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cato, M.C, Homan, K.T, Tesmer, J.J.G.
登録日2017-01-23
公開日2017-04-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
1AZT
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BU of 1azt by Molmil
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1997-11-20
公開日1998-02-25
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1APB
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BU of 1apb by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-D-fucopyranose, beta-D-fucopyranose
著者Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
登録日1991-11-15
公開日1992-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
1BAP
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BU of 1bap by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-L-arabinopyranose, beta-L-arabinopyranose
著者Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
登録日1991-11-15
公開日1992-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
6D8Z
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BU of 6d8z by Molmil
Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio
分子名称: Triple functional domain protein
著者Bandekar, S, Tesmer, J.J.
登録日2018-04-27
公開日2019-02-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.
Sci Signal, 12, 2019
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