6GWA
| Concanavalin B structure determined with data from the EuXFEL, the first MHz free electron laser | 分子名称: | Concanavalin B | 著者 | Gruenbein, M.L, Gorel, A, Stricker, M, Bean, R, Bielecki, J, Doerner, K, Hartmann, E, Hilpert, M, Kloos, M, Letrun, R, Sztuk-Dambietz, J, Mancuso, A, Meserschmidt, M, Nass-Kovacs, G, Ramilli, M, Roome, C.M, Sato, T, Doak, R.B, Shoeman, R.L, Foucar, L, Colletier, J.P, Barends, T.R.M, Stan, C, Schlichting, I. | 登録日 | 2018-06-22 | 公開日 | 2018-09-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Megahertz data collection from protein microcrystals at an X-ray free-electron laser. Nat Commun, 9, 2018
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8UWL
| 5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | 分子名称: | 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2023-11-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery. Science, 384, 2024
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2QMQ
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4BBW
| The crystal structure of Sialidase VPI 5482 (BTSA) from Bacteroides thetaiotaomicron | 分子名称: | SIALIDASE (NEURAMINIDASE) | 著者 | Park, K.-H, Song, H.-N, Jung, T.-Y, Lee, M.-H, Woo, E.-J. | 登録日 | 2012-09-28 | 公開日 | 2013-08-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Biochemical Characterization of the Broad Substrate Specificity of Bacteroides Thetaiotaomicron Commensal Sialidase. Biochim.Biophys.Acta, 1834, 2013
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7YQ3
| human insulin receptor bound with A43 DNA aptamer and insulin | 分子名称: | IR-A43 aptamer, Insulin A chain, Insulin, ... | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ4
| human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | 分子名称: | IR-A62 aptamer, Insulin A chain, Insulin, ... | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ6
| human insulin receptor bound with A62 DNA aptamer | 分子名称: | IR-A62 aptamer, Isoform Short of Insulin receptor | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ5
| human insulin receptor bound with A62 DNA aptamer and insulin | 分子名称: | IR-A62 aptamer, Insulin A chain, Insulin, ... | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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6WEB
| Multi-Hit SFX using MHz XFEL sources | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Holmes, S, Darmanin, C, Abbey, B. | 登録日 | 2020-04-01 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers. Nat Commun, 13, 2022
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6WEC
| Multi-Hit SFX using MHz XFEL sources | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Holmes, S, Darmanin, C, Abbey, B. | 登録日 | 2020-04-01 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers. Nat Commun, 13, 2022
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8V6U
| 5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking | 分子名称: | 4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol, 5-hydroxytryptamine receptor 2A, G protein alpha-subunit q (Gi2-mini-Gq chimera), ... | 著者 | Gumpper, R.H, Wang, L, Kapolka, N, Skiniotis, G, Roth, B.L. | 登録日 | 2023-12-03 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery. Science, 384, 2024
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6PFY
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7BXA
| Crystal structure of PD-1 in complex with tislelizumab Fab | 分子名称: | Programmed cell death protein 1, heavy chain, light chain | 著者 | Heo, Y.S, Lee, S.H, Lim, H, Lee, H.T, Kim, Y.J, Park, E.B. | 登録日 | 2020-04-18 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy. Biochem.Biophys.Res.Commun., 527, 2020
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5F3W
| Structure of the ATPrS-Mre11/Rad50-DNA complex | 分子名称: | 27-MER DNA, DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ... | 著者 | Liu, Y. | 登録日 | 2015-12-03 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex Embo J., 35, 2016
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3M16
| Structure of a Transaldolase from Oleispira antarctica | 分子名称: | Transaldolase | 著者 | Singer, A.U, Kagan, O, Zhang, R, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2010-03-04 | 公開日 | 2010-06-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica. Nat Commun, 4, 2013
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5DNY
| Structure of the ATPrS-Mre11/Rad50-DNA complex | 分子名称: | DNA (27-MER), DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ... | 著者 | Liu, Y. | 登録日 | 2015-09-10 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex. Embo J., 35, 2016
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7B3O
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7N6H
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7N6O
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5A34
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7OC9
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4AP9
| Crystal structure of phosphoserine phosphatase from T. onnurineus in complex with NDSB-201 | 分子名称: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, PHOSPHOSERINE PHOSPHATASE | 著者 | Jung, T.-Y, Kim, Y.-S, Song, H.-N, Woo, E. | 登録日 | 2012-03-31 | 公開日 | 2012-12-26 | 最終更新日 | 2013-04-17 | 実験手法 | X-RAY DIFFRACTION (1.783 Å) | 主引用文献 | Identification of a Novel Ligand Binding Site in Phosphoserine Phosphatase from the Hyperthermophilic Archaeon Thermococcus Onnurineus. Proteins, 81, 2013
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8ECZ
| Bovine Fab 4C1 | 分子名称: | 4C1 Fab heavy chain, 4C1 Fab light chain, PHOSPHATE ION | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EDF
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8ECQ
| Bovine Fab 2G3 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2G3 Fab Heavy chain, 2G3 Fab Light chain, ... | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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