8KD3
 
 | | Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA | | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | | 登録日 | 2023-08-09 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
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8KD6
 | | Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3 | | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | | 登録日 | 2023-08-09 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
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8KD4
 | | Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1 | | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | | 登録日 | 2023-08-09 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
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8KC7
 | | Rpd3S histone deacetylase complex | | 分子名称: | Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... | | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | | 登録日 | 2023-08-06 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
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8KD2
 | | Rpd3S in complex with 187bp nucleosome | | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | | 登録日 | 2023-08-09 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
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8KD7
 | | Rpd3S in complex with nucleosome with H3K36MLA modification and 167bp DNA | | 分子名称: | 167bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. | | 登録日 | 2023-08-09 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
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3EPO
 | | Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P | | 分子名称: | (4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL DIHYDROGEN PHOSPHATE, Thiamine biosynthesis protein thiC | | 著者 | Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E. | | 登録日 | 2008-09-29 | | 公開日 | 2008-10-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol., 4, 2008
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7AW0
 | | MerTK kinase domain in complex with purine inhibitor | | 分子名称: | 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine, Tyrosine-protein kinase Mer | | 著者 | Schimpl, M, Nissink, J.W.M, Blackett, C, Clarke, M, Disch, J, Goldberg, K, Guilinger, J, Hennessy, E.J, Jetson, R, Ginkunja, D, Hardaker, E, Keefe, A, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S, Zhang, Y. | | 登録日 | 2020-11-06 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.893 Å) | | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64, 2021
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3EPM
 | | Crystal structure of Caulobacter crescentus ThiC | | 分子名称: | 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE, SULFATE ION, Thiamine biosynthesis protein thiC, ... | | 著者 | Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E. | | 登録日 | 2008-09-29 | | 公開日 | 2008-10-28 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.793 Å) | | 主引用文献 | Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol., 4, 2008
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3EPN
 | | Crystal structure of Caulobacter crescentus ThiC complexed with imidazole ribonucleotide | | 分子名称: | 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, Thiamine biosynthesis protein thiC | | 著者 | Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E. | | 登録日 | 2008-09-29 | | 公開日 | 2008-10-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol., 4, 2008
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7XW9
 | | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y. | | 登録日 | 2022-05-26 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Cell Discov, 8, 2022
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8JOL
 | | cryo-EM structure of the CED-4/CED-3 holoenzyme | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 3, Cell death protein 4, ... | | 著者 | Li, Y, Tian, L, Zhang, Y, Shi, Y. | | 登録日 | 2023-06-07 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
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7YVR
 | | Crystal Structure of L-Threonine Aldolase from Neptunomonas marina | | 分子名称: | GLYCEROL, L-threonine aldolase | | 著者 | He, Y.Z, Wang, J, Yan, W.P, Zhang, Y, Feng, Y. | | 登録日 | 2022-08-19 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of beta-Hydroxy-alpha-amino Acids via C-C Formation
Acs Catalysis, 2023
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7TCL
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5HMB
 | | Crystal structure of S. sahachiroi AziG | | 分子名称: | Azi13, SULFATE ION | | 著者 | Erb, M.S, Zhang, Y, Ealick, S.E. | | 登録日 | 2016-01-15 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.
Biochemistry, 55, 2016
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8QSO
 | | Crystal structure of human Mcl-1 in complex with compound 1 | | 分子名称: | (13S,16R,19S)-16-benzyl-43-ethoxy-N-methyl-7,11,14,17-tetraoxo-13-phenyl-5-oxa-2,8,12,15,18-pentaaza-1(1,4),4(1,2)-dibenzena-9(1,4)-cyclohexanacycloicosaphane-19-carboxamide, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Hekking, K.F.W, Gremmen, S, Maroto, S, Keefe, A.D, Zhang, Y. | | 登録日 | 2023-10-10 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.106 Å) | | 主引用文献 | Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
J.Med.Chem., 67, 2024
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7SH6
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7Y35
 | | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | | 分子名称: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | | 登録日 | 2022-06-09 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
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5XDZ
 | | Crystal structure of zebrafish SNX25 PX domain | | 分子名称: | CHLORIDE ION, Cellular trafficking protein, SODIUM ION | | 著者 | Su, K, Zhang, Y, Xu, J, Liu, J. | | 登録日 | 2017-03-30 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain
FEBS Lett., 591, 2017
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8E3S
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7Y36
 | | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | | 登録日 | 2022-06-10 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published
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8FZR
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2JOA
 | | HtrA1 bound to an optimized peptide: NMR assignment of PDZ domain and ligand resonances | | 分子名称: | Peptide H1-C1, Serine protease HTRA1 | | 著者 | Runyon, S.T, Zhang, Y, Appleton, B.A, Sazinksy, S.L, Wu, P, Pan, B, Wiesmann, C, Skelton, N.J, Sidhu, S.S. | | 登録日 | 2007-03-01 | | 公開日 | 2007-11-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3
Protein Sci., 16, 2007
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6V4P
 | | Structure of the integrin AlphaIIbBeta3-Abciximab complex | | 分子名称: | Abciximab, heavy chain, light chain, ... | | 著者 | Nesic, D, Zhang, Y, Spasic, A, Li, J, Provasi, D, Filizola, M, Walz, T, Coller, B.S. | | 登録日 | 2019-11-28 | | 公開日 | 2020-02-05 | | 最終更新日 | 2020-03-11 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex.
Arterioscler Thromb Vasc Biol., 40, 2020
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2LD7
 | | Solution structure of the mSin3A PAH3-SAP30 SID complex | | 分子名称: | Histone deacetylase complex subunit SAP30, Paired amphipathic helix protein Sin3a | | 著者 | Xie, T, He, Y, Korkeamaki, H, Zhang, Y, Imhoff, R, Lohi, O, Radhakrishnan, I. | | 登録日 | 2011-05-16 | | 公開日 | 2011-06-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding.
J.Biol.Chem., 286, 2011
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