4P5K
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![BU of 4p5k by Molmil](/molmil-images/mine/4p5k) | Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergy and Autoimmunity | 分子名称: | HLA class II histocompatibility antigen, DP alpha 1 chain, RAS peptide,HLA class II histocompatibility antigen, ... | 著者 | Clayton, G.M, Wang, Y, Crawford, F, Novikov, A, Wimberly, B.T, Kieft, J.S, Falta, M.T, Bowerman, N.A, Marrack, P, Fontenot, A.P, Dai, S, Kappler, J.W. | 登録日 | 2014-03-17 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell, 158, 2014
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4EYR
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![BU of 4eyr by Molmil](/molmil-images/mine/4eyr) | Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir | 分子名称: | HIV-1 PROTEASE, RITONAVIR | 著者 | Liu, Z, Yedidi, R.S, Wang, Y, Brunzelle, J.S, Kovari, I.A, Kovari, L.C. | 登録日 | 2012-05-01 | 公開日 | 2013-01-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex. Biochem.Biophys.Res.Commun., 431, 2013
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4KO5
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![BU of 4ko5 by Molmil](/molmil-images/mine/4ko5) | Investigating the functional significance of the interlocked pair structural determinants in Pseudomonas aeruginosa azurin (V31I/W48L/V95I/Y108F) | 分子名称: | Azurin, COPPER (II) ION | 著者 | Inampudi, K.K, Wang, Y, Meng, W, Tobin, P.H, Wilson, C.J. | 登録日 | 2013-05-11 | 公開日 | 2014-05-14 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Investigating the functional significance of the interlocked pair structural determinants in Pseudomonas aeruginosa azurin (V31I/W48L/V95I/Y108F) To be Published
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4GYE
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![BU of 4gye by Molmil](/molmil-images/mine/4gye) | MDR 769 HIV-1 Protease in Complex with Reduced P1F | 分子名称: | P1F peptide, Protease | 著者 | Dewdney, T.G, Wang, Y, Brunzelle, J, Reiter, S.J, Kovari, I.A, Kovari, L.C. | 登録日 | 2012-09-05 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg.Med.Chem., 21, 2013
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8H0O
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![BU of 8h0o by Molmil](/molmil-images/mine/8h0o) | Crystal structure of human serum albumin and ruthenium PZA complex adduct | 分子名称: | Albumin, CHLORIDE ION, NITRIC OXIDE, ... | 著者 | Gong, W.J, Wang, Y, Bai, H.H, Wang, W.M, Wang, H.F. | 登録日 | 2022-09-30 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.479 Å) | 主引用文献 | Crystal structure of human serum albumin and ruthenium PZA complex adduct To Be Published
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4EKU
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![BU of 4eku by Molmil](/molmil-images/mine/4eku) | |
4GZF
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![BU of 4gzf by Molmil](/molmil-images/mine/4gzf) | Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide | 分子名称: | LrF peptide, Protease | 著者 | Dewdney, T.G, Wang, Y, Kovari, I.A, Brunzelle, J.S, Reiter, S.J, Kovari, L.C. | 登録日 | 2012-09-06 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg.Med.Chem., 21, 2013
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4L1A
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![BU of 4l1a by Molmil](/molmil-images/mine/4l1a) | Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance | 分子名称: | MDR769 HIV-1 protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | 著者 | Liu, Z, Yedidi, R.S, Wang, Y, Dewdney, T, Reiter, S, Brunzelle, J, Kovari, I, Kovari, L. | 登録日 | 2013-06-03 | 公開日 | 2014-04-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance. Biochem.Biophys.Res.Commun., 437, 2013
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4LOF
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![BU of 4lof by Molmil](/molmil-images/mine/4lof) | Human p53 Core Domain Mutant V157F/N235K/N239Y | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Wallentine, B.D, Wang, Y, Luecke, H. | 登録日 | 2013-07-12 | 公開日 | 2013-07-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue. Acta Crystallogr.,Sect.D, 69, 2013
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4LOE
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![BU of 4loe by Molmil](/molmil-images/mine/4loe) | Human p53 Core Domain Mutant N239Y | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Wallentine, B.D, Wang, Y, Luecke, H. | 登録日 | 2013-07-12 | 公開日 | 2013-07-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue. Acta Crystallogr.,Sect.D, 69, 2013
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4EG2
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![BU of 4eg2 by Molmil](/molmil-images/mine/4eg2) | 2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine | 分子名称: | ACETATE ION, Cytidine deaminase, MAGNESIUM ION, ... | 著者 | Minasov, G, Wawrzak, Z, Skarina, T, Wang, Y, Grimshaw, S, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-03-30 | 公開日 | 2012-05-02 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | 2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine. TO BE PUBLISHED
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4KVP
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![BU of 4kvp by Molmil](/molmil-images/mine/4kvp) | Human p53 Core Domain Mutant V157F | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Wallentine, B.D, Wang, Y, Luecke, H. | 登録日 | 2013-05-22 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue. Acta Crystallogr.,Sect.D, 69, 2013
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3W9K
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![BU of 3w9k by Molmil](/molmil-images/mine/3w9k) | Crystal structure of thermoacidophile-specific protein STK_08120 complexed with myristic acid | 分子名称: | FATTY ACID-BINDING PROTEIN, MYRISTIC ACID | 著者 | Miyakawa, T, Sawano, Y, Miyazono, K, Miyauchi, Y, Hatano, K, Tanokura, M. | 登録日 | 2013-04-05 | 公開日 | 2013-07-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A thermoacidophile-specific protein family, DUF3211, functions as a fatty acid carrier with novel binding mode. J.Bacteriol., 195, 2013
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4LO9
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![BU of 4lo9 by Molmil](/molmil-images/mine/4lo9) | Human p53 Core Domain Mutant N235K | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Wallentine, B.D, Wang, Y, Luecke, H. | 登録日 | 2013-07-12 | 公開日 | 2013-07-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue. Acta Crystallogr.,Sect.D, 69, 2013
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5XG7
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![BU of 5xg7 by Molmil](/molmil-images/mine/5xg7) | Galectin-13/Placental Protein 13 crystal structure | 分子名称: | Galactoside-binding soluble lectin 13 | 著者 | Su, J.Y, Wang, Y. | 登録日 | 2017-04-12 | 公開日 | 2018-01-31 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138 Sci Rep, 8, 2018
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8YM2
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![BU of 8ym2 by Molmil](/molmil-images/mine/8ym2) | Crystal structure of AIDA-1 PTB domain in complex with SynGAP NPxF motif | 分子名称: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Ras/Rap GTPase-activating protein SynGAP | 著者 | Wang, X, Wang, Y, Cai, Q, Zhang, M. | 登録日 | 2024-03-08 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity. J.Mol.Biol., 436, 2024
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7E35
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![BU of 7e35 by Molmil](/molmil-images/mine/7e35) | Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43 | 分子名称: | N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Non-structural protein 3, ZINC ION | 著者 | Liu, J, Wang, Y, Xu, X, Pan, L. | 登録日 | 2021-02-08 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol, 28, 2021
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5XHC
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![BU of 5xhc by Molmil](/molmil-images/mine/5xhc) | Crystal structure of T2R-TTL-PO10 complex | 分子名称: | (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(4-fluorophenyl)carbonylphenyl]methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-20 | 公開日 | 2017-10-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5XI5
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![BU of 5xi5 by Molmil](/molmil-images/mine/5xi5) | Crystal structure of T2R-TTL-PO5 complex | 分子名称: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-26 | 公開日 | 2017-10-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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7F0X
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![BU of 7f0x by Molmil](/molmil-images/mine/7f0x) | A SARS-CoV-2 neutralizing antibody | 分子名称: | Antibody, Spike protein S1 | 著者 | Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S. | 登録日 | 2021-06-07 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A SARS-CoV-2 neutralizing
antibody To Be Published
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7F12
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![BU of 7f12 by Molmil](/molmil-images/mine/7f12) | A SARS-CoV-2 neutralizing antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody, Spike protein S1 | 著者 | Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S. | 登録日 | 2021-06-07 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | A SARS-CoV-2 neutralizing
antibody To Be Published
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7F15
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![BU of 7f15 by Molmil](/molmil-images/mine/7f15) | A SARS-CoV-2 neutralizing antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody, Spike protein S1 | 著者 | Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S. | 登録日 | 2021-06-07 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | A SARS-CoV-2 neutralizing
antibody To Be Published
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8WQR
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![BU of 8wqr by Molmil](/molmil-images/mine/8wqr) | Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation | 分子名称: | Activating molecule in BECN1-regulated autophagy protein 1, DNA damage-binding protein 1 | 著者 | Liu, M, Wang, Y, Su, M.Y, Stjepanovic, G. | 登録日 | 2023-10-12 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation. Nat Commun, 14, 2023
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6JXR
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![BU of 6jxr by Molmil](/molmil-images/mine/6jxr) | Structure of human T cell receptor-CD3 complex | 分子名称: | T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, T-cell surface glycoprotein CD3 delta chain, ... | 著者 | Dong, D, Zheng, L, Lin, J, Zhu, Y, Li, N, Zhang, B, Xie, S, Zheng, J, Wang, Y, Gao, N, Huang, Z. | 登録日 | 2019-04-24 | 公開日 | 2019-09-11 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of assembly of the human T cell receptor-CD3 complex. Nature, 573, 2019
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6K3Z
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![BU of 6k3z by Molmil](/molmil-images/mine/6k3z) | Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) | 分子名称: | CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ... | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | 登録日 | 2019-05-22 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
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