4L1A

Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance

Summary for 4L1A

Entry DOI	10.2210/pdb4l1a/pdb
Descriptor	MDR769 HIV-1 protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total)
Functional Keywords	hiv-1 protease, multi-drug resistance, ic50, lopinavir, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 (HIV-1) More
Total number of polymer chains	2
Total formula weight	22170.04
Authors	Liu, Z.,Yedidi, R.S.,Wang, Y.,Dewdney, T.,Reiter, S.,Brunzelle, J.,Kovari, I.,Kovari, L. (deposition date: 2013-06-03, release date: 2014-04-02, Last modification date: 2024-02-28)
Primary citation	Liu, Z.,Yedidi, R.S.,Wang, Y.,Dewdney, T.G.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance. Biochem.Biophys.Res.Commun., 437:199-204, 2013 Cited by PubMed: 23792096 DOI: 10.1016/j.bbrc.2013.06.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation