4L1A
Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | MDR769 HIV-1 protease | polymer | 99 | 10769.6 | 1 | UniProt (Q000H7) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
2 | B | MDR769 HIV-1 protease | polymer | 99 | 10771.6 | 1 | UniProt (Q000H7) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
3 | A | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) | |||
4 | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q000H7)
B: 1 - 99 (UniProt: Q000H7)
PDB | External Database | Details |
---|---|---|
Asn 25 | Asp 25 | variant |
Glu 35 | Asp 35 | variant |
Val 36 | Ile 36 | variant |
Leu 46 | Met 46 | variant |
PDB | External Database | Details |
---|---|---|
Asn 25 | Asp 25 | variant |
Glu 35 | Asp 35 | variant |
Val 36 | Ile 36 | variant |
Leu 46 | Met 46 | variant |
Thr 71 | Val 71 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21541.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 628.8 | |
All* | Total formula weight | 22170.0 |