4LN0
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![BU of 4ln0 by Molmil](/molmil-images/mine/4ln0) | Crystal structure of the VGLL4-TEAD4 complex | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Transcription cofactor vestigial-like protein 4, ... | 著者 | Wang, H, Shi, Z, Zhou, Z. | 登録日 | 2013-07-11 | 公開日 | 2014-02-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.896 Å) | 主引用文献 | A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell, 25, 2014
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3E7J
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5CHL
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![BU of 5chl by Molmil](/molmil-images/mine/5chl) | Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex | 分子名称: | Histone H2A.Z, Vacuolar protein sorting-associated protein 72 homolog | 著者 | Shan, S, Liang, X, Pan, L, Wu, C, Zhou, Z. | 登録日 | 2015-07-10 | 公開日 | 2016-03-09 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1 Nat.Struct.Mol.Biol., 23, 2016
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3W94
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8GT6
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![BU of 8gt6 by Molmil](/molmil-images/mine/8gt6) | human STING With agonist HB3089 | 分子名称: | 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxamide, Stimulator of interferon genes protein | 著者 | Wang, Z, Yu, X. | 登録日 | 2022-09-07 | 公開日 | 2022-12-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation. Cell Discov, 8, 2022
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8GSZ
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![BU of 8gsz by Molmil](/molmil-images/mine/8gsz) | Structure of STING SAVI-related mutant V147L | 分子名称: | Stimulator of interferon genes protein | 著者 | Wang, Z, Yu, X. | 登録日 | 2022-09-07 | 公開日 | 2022-12-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation. Cell Discov, 8, 2022
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7WNT
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![BU of 7wnt by Molmil](/molmil-images/mine/7wnt) | RNase J from Mycobacterium tuberculosis | 分子名称: | Ribonuclease J, ZINC ION | 著者 | Li, J, Bao, L, Hu, J, Zhan, B, Li, Z. | 登録日 | 2022-01-19 | 公開日 | 2023-01-25 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism Nat Commun, 14, 2023
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7WNU
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![BU of 7wnu by Molmil](/molmil-images/mine/7wnu) | Mycobacterium tuberculosis Rnase J complex with 7nt RNA | 分子名称: | RNA (5'-R(P*AP*AP*AP*AP*AP*AP*A)-3'), Ribonuclease J, ZINC ION | 著者 | Li, J, Hu, J, Bao, L, Zhan, B, Li, Z. | 登録日 | 2022-01-19 | 公開日 | 2023-01-25 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism Nat Commun, 14, 2023
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4N6J
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![BU of 4n6j by Molmil](/molmil-images/mine/4n6j) | Crystal structure of human Striatin-3 coiled coil domain | 分子名称: | Striatin-3 | 著者 | Chen, C, Shi, Z, Zhou, Z. | 登録日 | 2013-10-13 | 公開日 | 2014-02-26 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. J.Biol.Chem., 289, 2014
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3E80
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5VJT
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![BU of 5vjt by Molmil](/molmil-images/mine/5vjt) | De Novo Photosynthetic Reaction Center Protein Equipped with Heme B and Zn(II) cations | 分子名称: | CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, Reaction Center Maquette, ... | 著者 | Ennist, N.M, Stayrook, S.E, Dutton, P.L, Moser, C.C. | 登録日 | 2017-04-19 | 公開日 | 2018-04-25 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | De novo protein design of photochemical reaction centers. Nat Commun, 13, 2022
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4NW7
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![BU of 4nw7 by Molmil](/molmil-images/mine/4nw7) | PDE4 catalytic domain | 分子名称: | (4-{[4-(3-chlorophenyl)-6-cyclopropyl-1,3,5-triazin-2-yl]amino}phenyl)acetic acid, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Fox III, D, Edwards, T.E. | 登録日 | 2013-12-05 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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8XSF
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![BU of 8xsf by Molmil](/molmil-images/mine/8xsf) | SARS-CoV-2 RBD + IMCAS-364 + hACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, IMCAS-364 H chain, ... | 著者 | Tong, Z, Cui, Y, Xie, Y, Tong, J, Gao, G.F, Qi, J. | 登録日 | 2024-01-09 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.16 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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8XSI
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![BU of 8xsi by Molmil](/molmil-images/mine/8xsi) | SARS-CoV-2 RBD + IMCAS-364 (Local Refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS-364 H chain, IMCAS-364 L chain, ... | 著者 | Tong, Z, Cui, Y, Xie, Y, Tong, J, Gao, G.F, Qi, J. | 登録日 | 2024-01-09 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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8XSE
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![BU of 8xse by Molmil](/molmil-images/mine/8xse) | SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS-123 H chain, IMCAS-123 L chain, ... | 著者 | Tong, Z, Cui, Y, Xie, Y, Tong, J, Gao, G.F, Qi, J. | 登録日 | 2024-01-09 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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8Y0Y
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![BU of 8y0y by Molmil](/molmil-images/mine/8y0y) | Cryo-EM structure of the 123-316 scDb/PT-RBD complex | 分子名称: | 123-316 scDb, 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Jia, G.W, Tong, Z, Tong, J.Y, Su, Z.M. | 登録日 | 2024-01-23 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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8XSJ
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![BU of 8xsj by Molmil](/molmil-images/mine/8xsj) | SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Tong, Z, Cui, Y, Xie, Y, Tong, J, Gao, G.F, Qi, J. | 登録日 | 2024-01-09 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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8XSL
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![BU of 8xsl by Molmil](/molmil-images/mine/8xsl) | SARS-CoV-2 spike + IMCAS-123 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS-123 heavy chain, ... | 著者 | Tong, Z, Cui, Y, Xie, Y, Tong, J, Gao, G.F, Qi, J. | 登録日 | 2024-01-09 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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5VMT
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4OCS
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![BU of 4ocs by Molmil](/molmil-images/mine/4ocs) | Crystal structure of human Fab CAP256-VRC26.10, a potent V1V2-directed HIV-1 neutralizing antibody | 分子名称: | CAP256-VRC26.10 heavy chain, CAP256-VRC26.10 light chain | 著者 | Gorman, J, Doria-Rose, N.A, Schramm, C.A, Moore, P.L, Mascola, J.R, Shapiro, L, Morris, L, Kwong, P.D. | 登録日 | 2014-01-09 | 公開日 | 2014-02-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature, 509, 2014
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5WA4
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4ZSE
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6M2B
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![BU of 6m2b by Molmil](/molmil-images/mine/6m2b) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416 | 分子名称: | 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Zhu, L, Li, H. | 登録日 | 2020-02-27 | 公開日 | 2021-03-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell, 11, 2020
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5BU3
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![BU of 5bu3 by Molmil](/molmil-images/mine/5bu3) | Crystal Structure of Diels-Alderase PyrI4 in complex with its product | 分子名称: | (4S,4aS,6aS,8R,9R,10aR,13R,14aS,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,5,6,6a,7,8,9,10,10a,13,14,18a,18b-hexadecahydro-1H-14a,17-(metheno)benzo[b]naphtho[2,1-h]azacyclododecine-16,18(15H,17H)-dione, GLYCEROL, PyrI4 | 著者 | Pan, L, Guo, Y, Liu, J. | 登録日 | 2015-06-03 | 公開日 | 2016-02-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | 主引用文献 | Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 Cell Chem Biol, 23, 2016
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5BTU
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