3E80
Structure of Heparinase II complexed with heparan sulfate degradation disaccharide product
Summary for 3E80
Entry DOI | 10.2210/pdb3e80/pdb |
Related | 3E7J |
Descriptor | Heparinase II protein, alpha-D-xylopyranose-(1-4)-alpha-D-glucopyranuronic acid-(1-2)-[alpha-L-rhamnopyranose-(1-4)]alpha-D-mannopyranose, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | alpha and beta lyase fold, alpha6/alpha6 incomplete toroid, sugar binding protein, lyase |
Biological source | Pedobacter heparinus |
Total number of polymer chains | 3 |
Total formula weight | 258968.51 |
Authors | Shaya, D.,Cygler, M. (deposition date: 2008-08-19, release date: 2008-12-30, Last modification date: 2023-08-30) |
Primary citation | Shaya, D.,Zhao, W.,Garron, M.L.,Xiao, Z.,Cui, Q.,Zhang, Z.,Sulea, T.,Linhardt, R.J.,Cygler, M. Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate. J.Biol.Chem., 285:20051-20061, 2010 Cited by PubMed: 20404324DOI: 10.1074/jbc.M110.101071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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