Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6M2B

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416

Summary for 6M2B
Entry DOI10.2210/pdb6m2b/pdb
DescriptorDihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total)
Functional Keywordsinhibitor, complex, biosynthetic protein, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight43620.69
Authors
Zhu, L.,Li, H. (deposition date: 2020-02-27, release date: 2021-03-03, Last modification date: 2023-11-29)
Primary citationXiong, R.,Zhang, L.,Li, S.,Sun, Y.,Ding, M.,Wang, Y.,Zhao, Y.,Wu, Y.,Shang, W.,Jiang, X.,Shan, J.,Shen, Z.,Tong, Y.,Xu, L.,Chen, Y.,Liu, Y.,Zou, G.,Lavillete, D.,Zhao, Z.,Wang, R.,Zhu, L.,Xiao, G.,Lan, K.,Li, H.,Xu, K.
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell, 11:723-739, 2020
Cited by
PubMed: 32754890
DOI: 10.1007/s13238-020-00768-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.76 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon