8W6P
 
 | | Crystal structure of dimeric murine SMPDL3A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | | 著者 | Zhang, C, Liu, P, Fan, S, Hou, Y. | | 登録日 | 2023-08-29 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Immunity, 56, 2023
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8W6R
 | | murine SMPDL3A bound to sulfate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | | 著者 | Zhang, C, Liu, P, Fan, S. | | 登録日 | 2023-08-29 | | 公開日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Immunity, 56, 2023
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7WL4
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50 | | 分子名称: | Bromodomain-containing protein 4, ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide | | 著者 | Zhang, C, Wang, C, Li, W, Zhang, Y, Xu, Y, Sun, L. | | 登録日 | 2022-01-12 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors.
Bioorg.Chem., 127, 2022
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7VT2
 | | Azumapecten Farreri ferritin | | 分子名称: | FE (III) ION, Ferritin | | 著者 | Zhao, G, Zhang, C. | | 登録日 | 2021-10-27 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural comparison between the DNA-protective ability of scallop and shrimp ferritin from iron-induced oxidative damage.
Food Chem, 386, 2022
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8IQY
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8IQV
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8IQZ
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8IQW
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8WCS
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7YZT
 | | Crystal structure of a dye-decolorizing (Dyp) peroxidase from Acinetobacter radioresistens | | 分子名称: | Dyp-type peroxidase family protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Zhang, C, Catucci, G, Gilardi, G, Sadeghi, S.J, Di Nardo, G. | | 登録日 | 2022-02-21 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of a decolorizing peroxidase (Dyp) from Acinetobacter radioresistens
To Be Published
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7X8K
 | | Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (product-bound) | | 分子名称: | CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, Mannose-1-phosphate guanylyltransferase 1, ... | | 著者 | Zhao, S, Zhang, C, Liu, L. | | 登録日 | 2022-03-13 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1.
Front Plant Sci, 13, 2022
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7X8J
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9J6O
 | | Crystal Structure of bromodomain of human CBP in complex with the inhibitor CZL-046 | | 分子名称: | (3~{S},5~{S})-1-[3,4-bis(fluoranyl)phenyl]-5-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]-3-fluoranyl-pyrrolidin-2-one, CHLORIDE ION, CREB-binding protein | | 著者 | Zhang, Y, Zhang, C, Chen, Z, Yang, H, Huang, X, Li, Y, Xu, Y. | | 登録日 | 2024-08-16 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Discovery of CZL-046 with an ( S )-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma.
J.Med.Chem., 2024
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9JE1
 | | Human URAT1 bound to dotinurad | | 分子名称: | Solute carrier family 22 member 12, dotinurad | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Biorxiv, 2024
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9JE0
 | | Human URAT1 bound to benzbromarone | | 分子名称: | Solute carrier family 22 member 12, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Biorxiv, 2024
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9JDV
 | | Human URAT1 bound with Uric acid | | 分子名称: | Solute carrier family 22 member 12, URIC ACID | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Biorxiv, 2024
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9JDY
 | | Human URAT1 bound with verinurad | | 分子名称: | Solute carrier family 22 member 12, verinurad | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Biorxiv, 2024
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7M3G
 | | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | | 分子名称: | 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G. | | 登録日 | 2021-03-18 | | 公開日 | 2021-06-30 | | 最終更新日 | 2021-07-21 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
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7M3E
 | | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ... | | 著者 | Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G. | | 登録日 | 2021-03-18 | | 公開日 | 2021-06-30 | | 最終更新日 | 2021-07-21 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
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7M3J
 | | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ... | | 著者 | Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G. | | 登録日 | 2021-03-18 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
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7M3F
 | | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G. | | 登録日 | 2021-03-18 | | 公開日 | 2021-06-30 | | 最終更新日 | 2021-07-21 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
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4RT7
 | | Crystal Structure of FLT3 with a small molecule inhibitor | | 分子名称: | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea, Receptor-type tyrosine-protein kinase FLT3 | | 著者 | Zhang, Y, Zhang, C. | | 登録日 | 2014-11-13 | | 公開日 | 2015-04-22 | | 最終更新日 | 2015-06-17 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Cancer Discov, 5, 2015
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6PGI
 | | Asymmetric functions of a binuclear metal cluster within the transport pathway of the ZIP transition metal transporters | | 分子名称: | BbZIP, CADMIUM ION | | 著者 | Zhang, T, Sui, D, Zhang, C, Logan, T, Hu, J. | | 登録日 | 2019-06-24 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.
Faseb J., 34, 2020
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3JAU
 | | The cryoEM map of EV71 mature viron in complex with the Fab fragment of antibody D5 | | 分子名称: | Capsid protein VP1, Heavy chain of Fab fragment variable region of antibody D5, Light chain of Fab fragment variable region of antibody D5 | | 著者 | Fan, C, Ye, X.H, Ku, Z.Q, Zuo, T, Kong, L.L, Zhang, C, Shi, J.P, Liu, Q.W, Chen, T, Zhang, Y.Y, Jiang, W, Zhang, L.Q, Huang, Z, Cong, Y. | | 登録日 | 2015-06-24 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody
Plos Pathog., 12, 2016
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6ODC
 | | Crystal structure of HDAC8 in complex with compound 30 | | 分子名称: | (2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide, 1,2-ETHANEDIOL, Histone deacetylase 8, ... | | 著者 | Zheng, X, Conti, C, Caravella, J, Zablocki, M.-M, Bair, K, Barczak, N, Han, B, Lancia Jr, D, Liu, C, Martin, M, Ng, P.Y, Rudnitskaya, A, Thomason, J.J, Garcia-Dancey, R, Hardy, C, Lahdenranta, J, Leng, C, Li, P, Pardo, E, Saldahna, A, Tan, T, Toms, A.V, Yao, L, Zhang, C. | | 登録日 | 2019-03-26 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors
To Be Published
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