4RT7

Crystal Structure of FLT3 with a small molecule inhibitor

Summary for 4RT7

• Entry DOI: 10.2210/pdb4rt7/pdb
• Descriptor: Receptor-type tyrosine-protein kinase FLT3, 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea (3 entities in total)
• Functional Keywords: kinase, transferase, transferase inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P36888
• Total number of polymer chains: 1
• Total formula weight: 48760.98

Authors

Zhang, Y.,Zhang, C. (deposition date: 2014-11-13, release date: 2015-04-22, Last modification date: 2015-06-17)

• Primary citation: Smith, C.C.,Zhang, C.,Lin, K.C.,Lasater, E.A.,Zhang, Y.,Massi, E.,Damon, L.E.,Pendleton, M.,Bashir, A.,Sebra, R.,Perl, A.,Kasarskis, A.,Shellooe, R.,Tsang, G.,Carias, H.,Powell, B.,Burton, E.A.,Matusow, B.,Zhang, J.,Spevak, W.,Ibrahim, P.N.,Le, M.H.,Hsu, H.H.,Habets, G.,West, B.L.,Bollag, G.,Shah, N.P.; Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.; Cancer Discov, 5:668-679, 2015; PubMed: 25847190; DOI: 10.1158/2159-8290.CD-15-0060

Experimental method

X-RAY DIFFRACTION (3.1 Å)