4RT7

Crystal Structure of FLT3 with a small molecule inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Receptor-type tyrosine-protein kinase FLT3	polymer	415	48200.3	1	UniProt (P36888) Pfam (PF07714)	Homo sapiens (human)	FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1
2	B (A)	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea	non-polymer		560.7	1	Chemie (P30)
3	C (A)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: 564 - 958 (UniProt: P36888)

PDB	External Database	Details
Met 544	-	expression tag
Ser 545	-	expression tag
Tyr 546	-	expression tag
Tyr 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
Ser 554	-	expression tag
Ser 555	-	expression tag
Gly 556	-	expression tag
Glu 557	-	expression tag
Asn 558	-	expression tag
Leu 559	-	expression tag
Tyr 560	-	expression tag
Phe 561	-	expression tag
Gln 562	-	expression tag
Gly 563	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	48200.3
Non-Polymers*	Number of molecules	1
	Total formula weight	560.7
All*	Total formula weight	48761.0

*Water molecules are not included.