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7M3J

Asymmetric Activation of the Calcium Sensing Receptor Homodimer

Summary for 7M3J
Entry DOI10.2210/pdb7m3j/pdb
EMDB information23655
DescriptorExtracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ... (5 entities in total)
Functional Keywordsgpcr, calcium sensing receptor, negative allosteric modulator, family c gpcr, membrane protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight206029.12
Authors
Gao, Y.,Robertson, M.J.,Zhang, C.,Meyerowitz, J.G.,Panova, O.,Skiniotis, G. (deposition date: 2021-03-18, release date: 2021-06-30, Last modification date: 2021-07-21)
Primary citationGao, Y.,Robertson, M.J.,Rahman, S.N.,Seven, A.B.,Zhang, C.,Meyerowitz, J.G.,Panova, O.,Hannan, F.M.,Thakker, R.V.,Brauner-Osborne, H.,Mathiesen, J.M.,Skiniotis, G.
Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595:455-459, 2021
Cited by
PubMed: 34194040
DOI: 10.1038/s41586-021-03691-0
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (4.1 Å)
Structure validation

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