7M3J
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00979 |
| Number of Residues | 19 |
| Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS |
| Chain | Residue | Details |
| A | VAL153-SER171 |
| site_id | PS00980 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC |
| Chain | Residue | Details |
| A | CYS561-CYS585 |
| site_id | PS00981 |
| Number of Residues | 11 |
| Details | G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfITFSM |
| Chain | Residue | Details |
| A | PHE801-MET811 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1264 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR20-PHE612 | |
| A | GLU671-GLN681 | |
| A | ALA746-SER769 | |
| A | TYR829-VAL836 | |
| B | TYR20-PHE612 | |
| B | GLU671-GLN681 | |
| B | ALA746-SER769 | |
| B | TYR829-VAL836 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY613-ILE635 | |
| B | GLY613-ILE635 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 96 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS636-GLU649 | |
| A | ARG701-GLN724 | |
| A | LYS793-LYS805 | |
| B | LYS636-GLU649 | |
| B | ARG701-GLN724 | |
| B | LYS793-LYS805 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU650-GLY670 | |
| B | LEU650-GLY670 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO682-ASN700 | |
| B | PRO682-ASN700 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE725-THR745 | |
| B | PHE725-THR745 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU770-PHE792 | |
| B | LEU770-PHE792 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE806-THR828 | |
| B | PHE806-THR828 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU837-PHE862 | |
| B | GLU837-PHE862 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S |
| Chain | Residue | Details |
| A | ARG66 | |
| B | ASP234 | |
| B | ARG415 | |
| B | GLY557 | |
| A | THR145 | |
| A | GLU231 | |
| A | ASP234 | |
| A | ARG415 | |
| A | GLY557 | |
| B | ARG66 | |
| B | THR145 | |
| B | GLU231 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S |
| Chain | Residue | Details |
| A | ILE81 | |
| A | LEU87 | |
| A | LEU88 | |
| B | ILE81 | |
| B | LEU87 | |
| B | LEU88 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S |
| Chain | Residue | Details |
| A | SER84 | |
| B | SER84 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S, ECO:0007744|PDB:5K5T |
| Chain | Residue | Details |
| A | THR100 | |
| B | THR100 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S |
| Chain | Residue | Details |
| A | SER147 | |
| A | ALA168 | |
| A | SER170 | |
| A | GLU297 | |
| B | SER147 | |
| B | ALA168 | |
| B | SER170 | |
| B | GLU297 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | SITE: Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity => ECO:0000269|PubMed:26290606 |
| Chain | Residue | Details |
| A | CYS482 | |
| B | CYS482 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN90 | |
| A | ASN130 | |
| A | ASN386 | |
| A | ASN400 | |
| B | ASN90 | |
| B | ASN130 | |
| B | ASN386 | |
| B | ASN400 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27434672 |
| Chain | Residue | Details |
| A | ASN261 | |
| B | ASN446 | |
| B | ASN468 | |
| B | ASN488 | |
| B | ASN541 | |
| B | ASN594 | |
| A | ASN287 | |
| A | ASN446 | |
| A | ASN468 | |
| A | ASN488 | |
| A | ASN541 | |
| A | ASN594 | |
| B | ASN261 | |
| B | ASN287 |
