7M3G

Asymmetric Activation of the Calcium Sensing Receptor Homodimer

Summary for 7M3G

Entry DOI	10.2210/pdb7m3g/pdb
EMDB information	23654
Descriptor	Extracellular calcium-sensing receptor, etelcalcetide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	gpcr, calcium sensing receptor, active state, positive allosteric modulator, family c gpcr, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	210058.86
Authors	Gao, Y.,Robertson, M.J.,Zhang, C.,Meyerowitz, J.G.,Panova, O.,Skiniotis, G. (deposition date: 2021-03-18, release date: 2021-06-30, Last modification date: 2021-07-21)
Primary citation	Gao, Y.,Robertson, M.J.,Rahman, S.N.,Seven, A.B.,Zhang, C.,Meyerowitz, J.G.,Panova, O.,Hannan, F.M.,Thakker, R.V.,Brauner-Osborne, H.,Mathiesen, J.M.,Skiniotis, G. Asymmetric activation of the calcium-sensing receptor homodimer. Nature, 595:455-459, 2021 Cited by PubMed: 34194040 DOI: 10.1038/s41586-021-03691-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation