7M3G
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Extracellular calcium-sensing receptor | polymer | 902 | 101745.4 | 2 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (Human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
| 2 | C, D (C, D) | etelcalcetide | polymer | 9 | 916.1 | 2 | synthetic construct | ||
| 3 | E, F, G, H, I (E, F, G, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | J, S (A, B) | 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid | non-polymer | 374.5 | 2 | Chemie (H43) | |||
| 5 | K, L, M, T, U (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | N, V (A, B) | TRYPTOPHAN | non-polymer | 204.2 | 2 | Chemie (TRP) | |||
| 7 | O, P, R, W (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 8 | Q, X (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) |
Sequence modifications
A, B: 20 - 894 (UniProt: P41180)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Lys -6 | - | expression tag |
| Thr -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Ile -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Tyr 1 | - | expression tag |
| Ile 2 | - | expression tag |
| Phe 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Val 6 | - | expression tag |
| Phe 7 | - | expression tag |
| Ala 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Lys 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Lys 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Ala 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 205323.2 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2613.7 | |
| All* | Total formula weight | 210058.9 |
