7M3G

Asymmetric Activation of the Calcium Sensing Receptor Homodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Extracellular calcium-sensing receptor	polymer	902	101745.4	2	UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB	Homo sapiens (Human)	CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2	C, D	etelcalcetide	polymer	9	916.1	2		synthetic construct
3	E, F, G, H, I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
4	A, B	2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid	non-polymer		374.5	2	Chemie (H43)
5	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6	A, B	TRYPTOPHAN	non-polymer		204.2	2	Chemie (TRP)
7	A, B	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
8	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)

Sequence modifications

A, B: 20 - 894 (UniProt: P41180)

PDB	External Database	Details
Met -7	-	initiating methionine
Lys -6	-	expression tag
Thr -5	-	expression tag
Ile -4	-	expression tag
Ile -3	-	expression tag
Ala -2	-	expression tag
Leu -1	-	expression tag
Ser 0	-	expression tag
Tyr 1	-	expression tag
Ile 2	-	expression tag
Phe 3	-	expression tag
Cys 4	-	expression tag
Leu 5	-	expression tag
Val 6	-	expression tag
Phe 7	-	expression tag
Ala 8	-	expression tag
Asp 9	-	expression tag
Tyr 10	-	expression tag
Lys 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Asp 15	-	expression tag
Lys 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
Ala 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	205323.2
Branched	Number of molecules	5
	Total formula weight	2122.0
Non-Polymers*	Number of molecules	15
	Total formula weight	2613.7
All*	Total formula weight	210058.9

*Water molecules are not included.