7WL4
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50
Summary for 7WL4
Entry DOI | 10.2210/pdb7wl4/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide (3 entities in total) |
Functional Keywords | bromodomain, brd4(1), inhibitor, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 69019.39 |
Authors | |
Primary citation | Li, W.,Zhang, C.,Zhang, H.E.,Dong, R.,Liu, J.Y.,Wang, C.M.,Wang, M.,Wang, Y.W.,Wang, C.,Zhang, Y.,Shi, L.,Xu, Y.,Sun, L.P. Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors. Bioorg.Chem., 127:105917-105917, 2022 Cited by PubMed: 35738217DOI: 10.1016/j.bioorg.2022.105917 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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