7WL4

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Bromodomain-containing protein 4	polymer	141	16767.3	4	UniProt (O60885) Pfam (PF00439)	Homo sapiens (human)	Protein HUNK1
2	E, F, G, H (A, C, D)	~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide	non-polymer		487.5	4	Chemie (JFU)
3	I, J, K, L (A, B, C, D)	water	water		18.0	343	Chemie (HOH)

Sequence modifications

A, B, C, D: 44 - 168 (UniProt: O60885)

PDB	External Database	Details
Met 28	-	expression tag
Lys 29	-	expression tag
Lys 30	-	expression tag
Gly 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
Leu 38	-	expression tag
Val 39	-	expression tag
Pro 40	-	expression tag
Arg 41	-	expression tag
Gly 42	-	expression tag
Ser 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	67069.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1950.1
All*	Total formula weight	69019.4

*Water molecules are not included.