7WL4
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Bromodomain-containing protein 4 | polymer | 141 | 16767.3 | 4 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
2 | A, C, D | ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide | non-polymer | 487.5 | 4 | Chemie (JFU) | |||
3 | water | water | 18.0 | 343 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 44 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 28 | - | expression tag |
Lys 29 | - | expression tag |
Lys 30 | - | expression tag |
Gly 31 | - | expression tag |
His 32 | - | expression tag |
His 33 | - | expression tag |
His 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
His 37 | - | expression tag |
Leu 38 | - | expression tag |
Val 39 | - | expression tag |
Pro 40 | - | expression tag |
Arg 41 | - | expression tag |
Gly 42 | - | expression tag |
Ser 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 67069.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1950.1 | |
All* | Total formula weight | 69019.4 |