8HCA
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![BU of 8hca by Molmil](/molmil-images/mine/8hca) | SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (1 RBD up) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of YB13-292 Fab, ... | 著者 | Liu, B, Gao, X, Chen, Q, Li, Z, Su, M, He, J, Xiong, X. | 登録日 | 2022-11-01 | 公開日 | 2023-01-25 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | 主引用文献 | Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. Nat Commun, 14, 2023
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8HC6
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![BU of 8hc6 by Molmil](/molmil-images/mine/8hc6) | SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with YB9-258 Fab, focused refinement of Fab region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of YB9-258 Fab, Light chain of YB9-258, ... | 著者 | Liu, B, Gao, X, Chen, Q, Li, Z, Su, M, He, J, Xiong, X. | 登録日 | 2022-11-01 | 公開日 | 2023-01-25 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (4.69 Å) | 主引用文献 | Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. Nat Commun, 14, 2023
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8WCN
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![BU of 8wcn by Molmil](/molmil-images/mine/8wcn) | Cryo-EM structure of PAO1-ImcA with GMPCPP | 分子名称: | Diguanylate cyclase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | 著者 | Zhan, X.L, Zhang, K, Wang, C.C, Fan, Q, Tang, X.J, Zhang, X, Wang, K, Fu, Y, Liang, H.H. | 登録日 | 2023-09-13 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. Nat Commun, 15, 2024
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8WM4
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8WML
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8WMC
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8WMI
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6KZD
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![BU of 6kzd by Molmil](/molmil-images/mine/6kzd) | Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide | 分子名称: | 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide, NT-3 growth factor receptor, PHOSPHATE ION | 著者 | Wang, Y, Zhang, Z.M. | 登録日 | 2019-09-23 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.708 Å) | 主引用文献 | Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur.J.Med.Chem., 179, 2019
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3GGQ
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![BU of 3ggq by Molmil](/molmil-images/mine/3ggq) | Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction | 分子名称: | BROMIDE ION, Capsid protein | 著者 | Li, S.W, Tang, X.H, Seetharaman, J, Yang, C.Y, Gu, Y, Zhang, J, Du, H.L, Shih, J.W.K, Hew, C.L, Sivaraman, J, Xia, N.S. | 登録日 | 2009-03-02 | 公開日 | 2009-08-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction Plos Pathog., 5, 2009
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4PLK
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4PLJ
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1MC0
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![BU of 1mc0 by Molmil](/molmil-images/mine/1mc0) | Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains | 分子名称: | 3',5'-cyclic nucleotide phosphodiesterase 2A, CYCLIC GUANOSINE MONOPHOSPHATE | 著者 | Martinez, S, Wu, A, Glavas, N, Tang, X, Turley, S, Hol, W, Beavo, J. | 登録日 | 2002-08-04 | 公開日 | 2002-10-02 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc.Natl.Acad.Sci.USA, 99, 2002
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8GVJ
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![BU of 8gvj by Molmil](/molmil-images/mine/8gvj) | Crystal structure of cMET kinase domain bound by D6808 | 分子名称: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | 著者 | Chen, Y.H, Qu, L.Z. | 登録日 | 2022-09-15 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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7BWJ
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![BU of 7bwj by Molmil](/molmil-images/mine/7bwj) | crystal structure of SARS-CoV-2 antibody with RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ... | 著者 | Wang, X, Ge, J. | 登録日 | 2020-04-14 | 公開日 | 2020-06-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 584, 2020
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8WCT
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6L3G
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![BU of 6l3g by Molmil](/molmil-images/mine/6l3g) | Structural Basis for DNA Unwinding at Forked dsDNA by two coordinating Pif1 helicases | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*TP*TP*TP*T)-3'), ... | 著者 | Su, N, Bharath, S.R, Song, H. | 登録日 | 2019-10-10 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases. Nat Commun, 10, 2019
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7YQE
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5FHF
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![BU of 5fhf by Molmil](/molmil-images/mine/5fhf) | Crystal structure of Bacteroides sp Pif1 in complex with ADP-AlF4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION, Uncharacterized protein | 著者 | Zhou, X, Ren, W, Bharath, S.R, Song, H. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
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5FHE
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![BU of 5fhe by Molmil](/molmil-images/mine/5fhe) | Crystal structure of Bacteroides Pif1 bound to ssDNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | 著者 | Zhou, X, Ren, W, Bharath, S.R, Song, H. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
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5FHG
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5FHH
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![BU of 5fhh by Molmil](/molmil-images/mine/5fhh) | Structure of human Pif1 helicase domain residues 200-641 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, TETRAFLUOROALUMINATE ION | 著者 | Zhou, X, Ren, W, Bharath, S.R, Song, H. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
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5FHD
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![BU of 5fhd by Molmil](/molmil-images/mine/5fhd) | Structure of Bacteroides sp Pif1 complexed with tailed dsDNA resulting in ssDNA bound complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*CP*CP*GP*GP*GP*GP*CP*CP*GP*CP*GP*C)-3'), MAGNESIUM ION, ... | 著者 | Zhou, X, Ren, W, Bharath, S.R, Song, H. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
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3RZ3
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![BU of 3rz3 by Molmil](/molmil-images/mine/3rz3) | Human Cdc34 E2 in complex with CC0651 inhibitor | 分子名称: | 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin-conjugating enzyme E2 R1 | 著者 | Ceccarelli, D.F, Webb, D.R, Sicheri, F. | 登録日 | 2011-05-11 | 公開日 | 2011-07-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme Cell(Cambridge,Mass.), 145, 2011
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5J0A
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![BU of 5j0a by Molmil](/molmil-images/mine/5j0a) | Crystal structure of PDZ-binding kinase | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Lymphokine-activated killer T-cell-originated protein kinase, SULFATE ION | 著者 | Zou, Q.W, Zhou, H, Yang, X. | 登録日 | 2016-03-28 | 公開日 | 2016-09-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | The crystal structure of an inactive dimer of PDZ-binding kinase Biochem.Biophys.Res.Commun., 476, 2016
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5BWA
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![BU of 5bwa by Molmil](/molmil-images/mine/5bwa) | Crystal structure of ODC-PLP-AZ1 ternary complex | 分子名称: | Ornithine decarboxylase, Ornithine decarboxylase antizyme 1, PYRIDOXAL-5'-PHOSPHATE | 著者 | Wu, D.H. | 登録日 | 2015-06-07 | 公開日 | 2015-12-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1 Sci Rep, 5, 2015
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