6Z88
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![BU of 6z88 by Molmil](/molmil-images/mine/6z88) | human GTP cyclohydrolase I in complex with allosteric inhibitor | 分子名称: | 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-06-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.687 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z89
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![BU of 6z89 by Molmil](/molmil-images/mine/6z89) | human GTP cyclohydrolase I in complex with allosteric inhibitor | 分子名称: | 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-06-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.366 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z80
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![BU of 6z80 by Molmil](/molmil-images/mine/6z80) | stimulatory human GTP cyclohydrolase I - GFRP complex | 分子名称: | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | 著者 | Ebenhoch, R, Nar, H, Vonck, J. | 登録日 | 2020-06-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z87
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![BU of 6z87 by Molmil](/molmil-images/mine/6z87) | human GTP cyclohydrolase I | 分子名称: | GTP cyclohydrolase 1, ZINC ION | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-06-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.564 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z85
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![BU of 6z85 by Molmil](/molmil-images/mine/6z85) | inhibitory human GTP cyclohydrolase I - GFRP complex | 分子名称: | 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | 著者 | Ebenhoch, R, Nar, H, Vonck, J. | 登録日 | 2020-06-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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4YGV
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![BU of 4ygv by Molmil](/molmil-images/mine/4ygv) | Reversal Agent for Dabigatran | 分子名称: | GLYCEROL, aDabi-Fab2a heavy chain, aDabi-Fab2a light chain | 著者 | Schiele, F, Nar, H. | 登録日 | 2015-02-26 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent. Mabs, 7, 2015
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4YHM
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![BU of 4yhm by Molmil](/molmil-images/mine/4yhm) | Reversal Agent for Dabigatran | 分子名称: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2b heavy chain, aDabi-Fab2b light chain | 著者 | Schiele, F, Nar, H. | 登録日 | 2015-02-27 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent. Mabs, 7, 2015
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4YHI
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![BU of 4yhi by Molmil](/molmil-images/mine/4yhi) | Reversal Agent for Dabigatran | 分子名称: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2a heavy chain, aDabi-Fab2a light chain | 著者 | Schiele, F, Nar, H. | 登録日 | 2015-02-27 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent. Mabs, 7, 2015
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4YHN
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![BU of 4yhn by Molmil](/molmil-images/mine/4yhn) | Dabigatran Reversal Agent | 分子名称: | aDabi-Fab3 heavy chain, aDabi-Fab3 light chain | 著者 | Schiele, F, Nar, H. | 登録日 | 2015-02-27 | 公開日 | 2016-02-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent. Mabs, 7, 2015
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4YHO
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![BU of 4yho by Molmil](/molmil-images/mine/4yho) | Reversal Agent for Dabigatran | 分子名称: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab3 heavy chain, aDabi-Fab3 light chain | 著者 | Schiele, F, Nar, H. | 登録日 | 2015-02-27 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent. Mabs, 7, 2015
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6ZLE
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![BU of 6zle by Molmil](/molmil-images/mine/6zle) | |
6SVL
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![BU of 6svl by Molmil](/molmil-images/mine/6svl) | |
6SVK
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![BU of 6svk by Molmil](/molmil-images/mine/6svk) | human Myeloid-derived growth factor (MYDGF) | 分子名称: | MALONATE ION, Myeloid-derived growth factor | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2019-09-18 | 公開日 | 2019-11-27 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | 主引用文献 | Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair. Nat Commun, 10, 2019
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7AL9
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![BU of 7al9 by Molmil](/molmil-images/mine/7al9) | |
7ALA
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![BU of 7ala by Molmil](/molmil-images/mine/7ala) | human GCH-GFRP inhibitory complex | 分子名称: | 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-10-06 | 公開日 | 2021-10-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.846 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALC
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![BU of 7alc by Molmil](/molmil-images/mine/7alc) | human GCH-GFRP stimulatory complex | 分子名称: | GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, PHENYLALANINE, ... | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-10-06 | 公開日 | 2021-10-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.726 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALB
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![BU of 7alb by Molmil](/molmil-images/mine/7alb) | human GCH-GFRP stimulatory complex 7-deaza-GTP bound | 分子名称: | 7-deaza-GTP, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-10-06 | 公開日 | 2021-10-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALQ
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![BU of 7alq by Molmil](/molmil-images/mine/7alq) | human GCH-GFRP inhibitory complex 7-deaza-GTP bound | 分子名称: | 7,8-DIHYDROBIOPTERIN, 7-deaza-GTP, GTP cyclohydrolase 1, ... | 著者 | Ebenhoch, R, Nar, H. | 登録日 | 2020-10-07 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.205 Å) | 主引用文献 | Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. J.Struct.Biol., 213, 2021
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7ACC
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![BU of 7acc by Molmil](/molmil-images/mine/7acc) | |
6ZPR
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![BU of 6zpr by Molmil](/molmil-images/mine/6zpr) | Solution structure of MLKL executioner domain in complex with a covalent inhibitor | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2020-07-09 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-06 | 実験手法 | SOLUTION NMR | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZZ1
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![BU of 6zz1 by Molmil](/molmil-images/mine/6zz1) | Crystal structure of MLKL executioner domain in complex with a covalent inhibitor | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein | 著者 | Fiegen, D, Bauer, M, Nar, H. | 登録日 | 2020-08-03 | 公開日 | 2020-12-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZVO
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![BU of 6zvo by Molmil](/molmil-images/mine/6zvo) | |
7NEV
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![BU of 7nev by Molmil](/molmil-images/mine/7nev) | Structure of the hemiacetal complex between the SARS-CoV-2 Main Protease and Leupeptin | 分子名称: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Guenther, S, Reinke, P.Y.A, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H.M, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashhour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Xavier, P.L, Ullah, N, Andaleeb, H, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Zaitsev-Doyle, J.J, Rogers, C, Gieseler, H, Melo, D, Monteiro, D.C.F, Dunkel, I, Lane, T.J, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schluenzen, F, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Sun, X, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. | 登録日 | 2021-02-05 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science, 372, 2021
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4LKC
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![BU of 4lkc by Molmil](/molmil-images/mine/4lkc) | |
4K8R
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![BU of 4k8r by Molmil](/molmil-images/mine/4k8r) | |