6Z88
 
 | | human GTP cyclohydrolase I in complex with allosteric inhibitor | | 分子名称: | 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.687 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z89
 | | human GTP cyclohydrolase I in complex with allosteric inhibitor | | 分子名称: | 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.366 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z80
 | | stimulatory human GTP cyclohydrolase I - GFRP complex | | 分子名称: | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | | 著者 | Ebenhoch, R, Nar, H, Vonck, J. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z87
 | | human GTP cyclohydrolase I | | 分子名称: | GTP cyclohydrolase 1, ZINC ION | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.564 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z85
 | | inhibitory human GTP cyclohydrolase I - GFRP complex | | 分子名称: | 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | | 著者 | Ebenhoch, R, Nar, H, Vonck, J. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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4YGV
 | | Reversal Agent for Dabigatran | | 分子名称: | GLYCEROL, aDabi-Fab2a heavy chain, aDabi-Fab2a light chain | | 著者 | Schiele, F, Nar, H. | | 登録日 | 2015-02-26 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHM
 | | Reversal Agent for Dabigatran | | 分子名称: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2b heavy chain, aDabi-Fab2b light chain | | 著者 | Schiele, F, Nar, H. | | 登録日 | 2015-02-27 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHI
 | | Reversal Agent for Dabigatran | | 分子名称: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2a heavy chain, aDabi-Fab2a light chain | | 著者 | Schiele, F, Nar, H. | | 登録日 | 2015-02-27 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHN
 | | Dabigatran Reversal Agent | | 分子名称: | aDabi-Fab3 heavy chain, aDabi-Fab3 light chain | | 著者 | Schiele, F, Nar, H. | | 登録日 | 2015-02-27 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHO
 | | Reversal Agent for Dabigatran | | 分子名称: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab3 heavy chain, aDabi-Fab3 light chain | | 著者 | Schiele, F, Nar, H. | | 登録日 | 2015-02-27 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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6ZLE
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6SVL
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6SVK
 | | human Myeloid-derived growth factor (MYDGF) | | 分子名称: | MALONATE ION, Myeloid-derived growth factor | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2019-09-18 | | 公開日 | 2019-11-27 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | | 主引用文献 | Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.
Nat Commun, 10, 2019
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7AL9
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7ALA
 | | human GCH-GFRP inhibitory complex | | 分子名称: | 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-10-06 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.846 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALC
 | | human GCH-GFRP stimulatory complex | | 分子名称: | GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, PHENYLALANINE, ... | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-10-06 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.726 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALB
 | | human GCH-GFRP stimulatory complex 7-deaza-GTP bound | | 分子名称: | 7-deaza-GTP, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-10-06 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7ALQ
 | | human GCH-GFRP inhibitory complex 7-deaza-GTP bound | | 分子名称: | 7,8-DIHYDROBIOPTERIN, 7-deaza-GTP, GTP cyclohydrolase 1, ... | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2020-10-07 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.205 Å) | | 主引用文献 | Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.
J.Struct.Biol., 213, 2021
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7ACC
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6ZPR
 | | Solution structure of MLKL executioner domain in complex with a covalent inhibitor | | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2020-07-09 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-01-06 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZZ1
 | | Crystal structure of MLKL executioner domain in complex with a covalent inhibitor | | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein | | 著者 | Fiegen, D, Bauer, M, Nar, H. | | 登録日 | 2020-08-03 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZVO
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7NEV
 | | Structure of the hemiacetal complex between the SARS-CoV-2 Main Protease and Leupeptin | | 分子名称: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Guenther, S, Reinke, P.Y.A, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H.M, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashhour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Xavier, P.L, Ullah, N, Andaleeb, H, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Zaitsev-Doyle, J.J, Rogers, C, Gieseler, H, Melo, D, Monteiro, D.C.F, Dunkel, I, Lane, T.J, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schluenzen, F, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Sun, X, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. | | 登録日 | 2021-02-05 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Science, 372, 2021
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4LKC
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4K8R
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