6Z85

inhibitory human GTP cyclohydrolase I - GFRP complex

Summary for 6Z85

Entry DOI	10.2210/pdb6z85/pdb
EMDB information	11114
Descriptor	GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ZINC ION, ... (4 entities in total)
Functional Keywords	gtp cyclohydrolase gftp, i, ec:3.5.4.16, tetrahydrobiopterin (bh4) synthesis, cytosol, zinc ion binding, hydrolase activity, metal ion binding, nucleotide binding, allosteric inhibited, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	20
Total formula weight	356220.43
Authors	Ebenhoch, R.,Nar, H.,Vonck, J. (deposition date: 2020-06-02, release date: 2020-12-09, Last modification date: 2024-05-22)
Primary citation	Ebenhoch, R.,Prinz, S.,Kaltwasser, S.,Mills, D.J.,Meinecke, R.,Rubbelke, M.,Reinert, D.,Bauer, M.,Weixler, L.,Zeeb, M.,Vonck, J.,Nar, H. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117:31838-31849, 2020 Cited by PubMed: 33229582 DOI: 10.1073/pnas.2013473117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation