6Z85

inhibitory human GTP cyclohydrolase I - GFRP complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, L, M, N, O... (A, C, D, B, E...)	GTP cyclohydrolase 1	polymer	224	25324.9	10	UniProt (P30793) Pfam (PF01227)	Homo sapiens (Human)	GTP cyclohydrolase I,GTP-CH-I
2	B, C, D, E, F... (K, L, M, N, O...)	GTP cyclohydrolase 1 feedback regulatory protein	polymer	87	9992.5	10	UniProt (P30047) Pfam (PF06399)	Homo sapiens (Human)	GFRP,GTP cyclohydrolase I feedback regulatory protein,p35
3	AA, CA, EA, GA, IA... (B, E, G, H, I...)	ZINC ION	non-polymer		65.4	10	Chemie (ZN)
4	BA, DA, FA, HA, JA... (B, E, G, H, I...)	7,8-DIHYDROBIOPTERIN	non-polymer		239.2	10	Chemie (HBI)

Sequence modifications

A, C, D, B, E, G, H, I, J, F: 41 - 250 (UniProt: P30793)

PDB	External Database	Details
Met 27	-	initiating methionine
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
Gly 34	-	expression tag
Ser 35	-	expression tag
Asp 36	-	expression tag
Asp 37	-	expression tag
Asp 38	-	expression tag
Asp 39	-	expression tag
Lys 40	-	expression tag

K, L, M, N, O, P, Q, R, S, T: 1 - 84 (UniProt: P30047)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	353174.0
Non-Polymers*	Number of molecules	20
	Total formula weight	3046.4
All*	Total formula weight	356220.4

*Water molecules are not included.