Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z85

inhibitory human GTP cyclohydrolase I - GFRP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process
K	0004857	molecular_function	enzyme inhibitor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009890	biological_process	negative regulation of biosynthetic process
K	0030425	cellular_component	dendrite
K	0031965	cellular_component	nuclear membrane
K	0042470	cellular_component	melanosome
K	0044549	molecular_function	GTP cyclohydrolase binding
K	0045428	biological_process	regulation of nitric oxide biosynthetic process
L	0004857	molecular_function	enzyme inhibitor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009890	biological_process	negative regulation of biosynthetic process
L	0030425	cellular_component	dendrite
L	0031965	cellular_component	nuclear membrane
L	0042470	cellular_component	melanosome
L	0044549	molecular_function	GTP cyclohydrolase binding
L	0045428	biological_process	regulation of nitric oxide biosynthetic process
M	0004857	molecular_function	enzyme inhibitor activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0009890	biological_process	negative regulation of biosynthetic process
M	0030425	cellular_component	dendrite
M	0031965	cellular_component	nuclear membrane
M	0042470	cellular_component	melanosome
M	0044549	molecular_function	GTP cyclohydrolase binding
M	0045428	biological_process	regulation of nitric oxide biosynthetic process
N	0004857	molecular_function	enzyme inhibitor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0009890	biological_process	negative regulation of biosynthetic process
N	0030425	cellular_component	dendrite
N	0031965	cellular_component	nuclear membrane
N	0042470	cellular_component	melanosome
N	0044549	molecular_function	GTP cyclohydrolase binding
N	0045428	biological_process	regulation of nitric oxide biosynthetic process
O	0004857	molecular_function	enzyme inhibitor activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0009890	biological_process	negative regulation of biosynthetic process
O	0030425	cellular_component	dendrite
O	0031965	cellular_component	nuclear membrane
O	0042470	cellular_component	melanosome
O	0044549	molecular_function	GTP cyclohydrolase binding
O	0045428	biological_process	regulation of nitric oxide biosynthetic process
P	0004857	molecular_function	enzyme inhibitor activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0009890	biological_process	negative regulation of biosynthetic process
P	0030425	cellular_component	dendrite
P	0031965	cellular_component	nuclear membrane
P	0042470	cellular_component	melanosome
P	0044549	molecular_function	GTP cyclohydrolase binding
P	0045428	biological_process	regulation of nitric oxide biosynthetic process
Q	0004857	molecular_function	enzyme inhibitor activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0009890	biological_process	negative regulation of biosynthetic process
Q	0030425	cellular_component	dendrite
Q	0031965	cellular_component	nuclear membrane
Q	0042470	cellular_component	melanosome
Q	0044549	molecular_function	GTP cyclohydrolase binding
Q	0045428	biological_process	regulation of nitric oxide biosynthetic process
R	0004857	molecular_function	enzyme inhibitor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0009890	biological_process	negative regulation of biosynthetic process
R	0030425	cellular_component	dendrite
R	0031965	cellular_component	nuclear membrane
R	0042470	cellular_component	melanosome
R	0044549	molecular_function	GTP cyclohydrolase binding
R	0045428	biological_process	regulation of nitric oxide biosynthetic process
S	0004857	molecular_function	enzyme inhibitor activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0009890	biological_process	negative regulation of biosynthetic process
S	0030425	cellular_component	dendrite
S	0031965	cellular_component	nuclear membrane
S	0042470	cellular_component	melanosome
S	0044549	molecular_function	GTP cyclohydrolase binding
S	0045428	biological_process	regulation of nitric oxide biosynthetic process
T	0004857	molecular_function	enzyme inhibitor activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0009890	biological_process	negative regulation of biosynthetic process
T	0030425	cellular_component	dendrite
T	0031965	cellular_component	nuclear membrane
T	0042470	cellular_component	melanosome
T	0044549	molecular_function	GTP cyclohydrolase binding
T	0045428	biological_process	regulation of nitric oxide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS141
A	HIS144
A	CYS212

site_id	AC2
Number of Residues	9
Details	binding site for residue HBI A 302

Chain	Residue
E	MET230
E	ARG235
E	ARG241
A	ASP127
A	LEU157
A	ASP237
A	THR240
A	GLU243
E	SER228

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN C 301

Chain	Residue
C	CYS141
C	HIS144
C	CYS212

site_id	AC4
Number of Residues	9
Details	binding site for residue HBI C 302

Chain	Residue
B	SER228
B	MET230
B	ARG235
B	ARG241
C	ASP127
C	LEU157
C	ASP237
C	THR240
C	GLU243

site_id	AC5
Number of Residues	3
Details	binding site for residue ZN D 301

Chain	Residue
D	CYS141
D	HIS144
D	CYS212

site_id	AC6
Number of Residues	9
Details	binding site for residue HBI D 302

Chain	Residue
C	SER228
C	MET230
C	ARG235
C	ARG241
D	ASP127
D	LEU157
D	ASP237
D	THR240
D	GLU243

site_id	AC7
Number of Residues	3
Details	binding site for residue ZN B 301

Chain	Residue
B	CYS141
B	HIS144
B	CYS212

site_id	AC8
Number of Residues	9
Details	binding site for residue HBI B 302

Chain	Residue
A	SER228
A	MET230
A	ARG235
A	ARG241
B	ASP127
B	LEU157
B	ASP237
B	THR240
B	GLU243

site_id	AC9
Number of Residues	3
Details	binding site for residue ZN E 301

Chain	Residue
E	CYS141
E	HIS144
E	CYS212

site_id	AD1
Number of Residues	9
Details	binding site for residue HBI E 302

Chain	Residue
D	SER228
D	MET230
D	ARG235
D	ARG241
E	ASP127
E	LEU157
E	ASP237
E	THR240
E	GLU243

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN G 301

Chain	Residue
G	CYS141
G	HIS144
G	CYS212

site_id	AD3
Number of Residues	9
Details	binding site for residue HBI G 302

Chain	Residue
F	SER228
F	MET230
F	ARG235
F	ARG241
G	ASP127
G	LEU157
G	ASP237
G	THR240
G	GLU243

site_id	AD4
Number of Residues	3
Details	binding site for residue ZN H 301

Chain	Residue
H	CYS141
H	HIS144
H	CYS212

site_id	AD5
Number of Residues	9
Details	binding site for residue HBI H 302

Chain	Residue
G	SER228
G	MET230
G	ARG235
G	ARG241
H	ASP127
H	LEU157
H	ASP237
H	THR240
H	GLU243

site_id	AD6
Number of Residues	3
Details	binding site for residue ZN I 301

Chain	Residue
I	CYS141
I	HIS144
I	CYS212

site_id	AD7
Number of Residues	9
Details	binding site for residue HBI I 302

Chain	Residue
H	SER228
H	MET230
H	ARG235
H	ARG241
I	ASP127
I	LEU157
I	ASP237
I	THR240
I	GLU243

site_id	AD8
Number of Residues	3
Details	binding site for residue ZN J 301

Chain	Residue
J	CYS141
J	HIS144
J	CYS212

site_id	AD9
Number of Residues	9
Details	binding site for residue HBI J 302

Chain	Residue
I	SER228
I	MET230
I	ARG235
I	ARG241
J	ASP127
J	LEU157
J	ASP237
J	THR240
J	GLU243

site_id	AE1
Number of Residues	3
Details	binding site for residue ZN F 301

Chain	Residue
F	CYS141
F	HIS144
F	CYS212

site_id	AE2
Number of Residues	9
Details	binding site for residue HBI F 302

Chain	Residue
F	ASP127
F	LEU157
F	ASP237
F	THR240
F	GLU243
J	SER228
J	MET230
J	ARG235
J	ARG241

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11087827","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17704208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)