6Z88
human GTP cyclohydrolase I in complex with allosteric inhibitor
Summary for 6Z88
| Entry DOI | 10.2210/pdb6z88/pdb |
| Descriptor | GTP cyclohydrolase 1, 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, ZINC ION, ... (4 entities in total) |
| Functional Keywords | gtp cyclohydrolase i, ec:3.5.4.16, tetrahydrobiopterin (bh4) synthesis, cytosol, zinc ion binding, hydrolase activity, metal ion binding, nucleotide binding, allosteric inhibitor, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 10 |
| Total formula weight | 255201.62 |
| Authors | Ebenhoch, R.,Nar, H. (deposition date: 2020-06-02, release date: 2020-12-09, Last modification date: 2024-01-24) |
| Primary citation | Ebenhoch, R.,Prinz, S.,Kaltwasser, S.,Mills, D.J.,Meinecke, R.,Rubbelke, M.,Reinert, D.,Bauer, M.,Weixler, L.,Zeeb, M.,Vonck, J.,Nar, H. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117:31838-31849, 2020 Cited by PubMed: 33229582DOI: 10.1073/pnas.2013473117 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.687 Å) |
Structure validation
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