6Z88

human GTP cyclohydrolase I in complex with allosteric inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	GTP cyclohydrolase 1	polymer	224	25324.9	10	UniProt (P30793) Pfam (PF01227)	Homo sapiens (Human)	GTP cyclohydrolase I,GTP-CH-I
2	K, L, N, O, P... (A, B, C, D, F...)	5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione	non-polymer		182.2	10	Chemie (QBK)
3	M, R (B, F)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	AA, BA, CA, DA, EA... (E, F, G, H, I...)	water	water		18.0	272	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J: 41 - 250 (UniProt: P30793)

PDB	External Database	Details
Met 27	-	initiating methionine
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
Gly 34	-	expression tag
Ser 35	-	expression tag
Asp 36	-	expression tag
Asp 37	-	expression tag
Asp 38	-	expression tag
Asp 39	-	expression tag
Lys 40	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	253249.2
Non-Polymers*	Number of molecules	12
	Total formula weight	1952.4
All*	Total formula weight	255201.6

*Water molecules are not included.