6Z88

human GTP cyclohydrolase I in complex with allosteric inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue QBK A 301

Chain	Residue
A	ASP127
A	MET129
A	LEU157
A	THR240
A	GLU243
E	SER228
E	ARG235
E	ARG241
E	HOH313

---

site_id	AC2
Number of Residues	9
Details	binding site for residue QBK A 302

Chain	Residue
A	SER228
A	MET230
A	ARG235
A	ARG241
C	ASP127
C	MET129
C	LEU157
C	THR240
C	GLU243

---

site_id	AC3
Number of Residues	2
Details	binding site for residue ZN B 301

Chain	Residue
B	CYS141
B	HIS144

---

site_id	AC4
Number of Residues	10
Details	binding site for residue QBK B 302

Chain	Residue
B	SER228
B	MET230
B	ARG235
B	ARG241
F	ASP127
F	MET129
F	LEU157
F	THR240
F	GLU243
F	HOH403

---

site_id	AC5
Number of Residues	11
Details	binding site for residue QBK C 301

Chain	Residue
C	SER228
C	MET230
C	ARG235
C	ARG241
C	HOH403
C	HOH406
I	ASP127
I	MET129
I	LEU157
I	THR240
I	GLU243

---

site_id	AC6
Number of Residues	8
Details	binding site for residue QBK D 301

Chain	Residue
B	ASP127
B	LEU157
B	THR240
B	GLU243
D	SER228
D	MET230
D	ARG235
D	ARG241

---

site_id	AC7
Number of Residues	8
Details	binding site for residue QBK D 302

Chain	Residue
D	LEU157
D	THR240
D	GLU243
D	HOH405
H	SER228
H	MET230
H	ARG235
H	ARG241

---

site_id	AC8
Number of Residues	8
Details	binding site for residue QBK F 302

Chain	Residue
F	SER228
F	MET230
F	ARG235
F	ARG241
J	ASP127
J	LEU157
J	THR240
J	GLU243

---

site_id	AC9
Number of Residues	8
Details	binding site for residue QBK G 301

Chain	Residue
E	LEU157
E	THR240
E	GLU243
E	HOH302
G	SER228
G	MET230
G	ARG235
G	ARG241

---

site_id	AD1
Number of Residues	10
Details	binding site for residue QBK G 302

Chain	Residue
G	ASP127
G	MET129
G	LEU157
G	THR240
G	GLU243
G	HOH402
I	SER228
I	MET230
I	ARG235
I	ARG241

---

site_id	AD2
Number of Residues	8
Details	binding site for residue QBK J 301

Chain	Residue
H	ASP127
H	LEU157
H	THR240
H	GLU243
J	SER228
J	MET230
J	ARG235
J	ARG241

---

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

---

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11087827","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17704208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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