4YHO

Reversal Agent for Dabigatran

Summary for 4YHO

DescriptoraDabi-Fab3 heavy chain, aDabi-Fab3 light chain, N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, ... (4 entities in total)
Functional Keywordsantibody, dabigatran, pradaxa, antidote, reversal agent, immune system
Biological sourceHomo sapiens
Total number of polymer chains2
Total molecular weight48355.96
Authors
Schiele, F.,Nar, H. (deposition date: 2015-02-27, release date: 2016-01-13)
Primary citation
Schiele, F.,van Ryn, J.,Litzenburger, T.,Ritter, M.,Seeliger, D.,Nar, H.
Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7:871-880, 2015
PubMed: 26047352 (PDB entries with the same primary citation)
DOI: 10.1080/19420862.2015.1057364
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2222 0.2% 1.8% 0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
170172
PDB entries from 2020-10-21