6Z89

human GTP cyclohydrolase I in complex with allosteric inhibitor

Summary for 6Z89

Entry DOI	10.2210/pdb6z89/pdb
Descriptor	GTP cyclohydrolase 1, 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, ZINC ION, ... (4 entities in total)
Functional Keywords	gtp cyclohydrolase i, ec:3.5.4.16, tetrahydrobiopterin (bh4) synthesis, cytosol, zinc ion binding, hydrolase activity, metal ion binding, nucleotide binding, allosteric inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	5
Total formula weight	127315.96
Authors	Ebenhoch, R.,Nar, H. (deposition date: 2020-06-02, release date: 2020-12-09, Last modification date: 2024-01-24)
Primary citation	Ebenhoch, R.,Prinz, S.,Kaltwasser, S.,Mills, D.J.,Meinecke, R.,Rubbelke, M.,Reinert, D.,Bauer, M.,Weixler, L.,Zeeb, M.,Vonck, J.,Nar, H. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117:31838-31849, 2020 Cited by PubMed: 33229582 DOI: 10.1073/pnas.2013473117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.366 Å)

Structure validation