6Z89
human GTP cyclohydrolase I in complex with allosteric inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| E | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| E | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue QBK A 301 |
| Chain | Residue |
| A | SER228 |
| A | MET230 |
| A | ARG241 |
| B | ASP127 |
| B | LEU157 |
| B | THR240 |
| B | GLU243 |
| B | HOH401 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | HIS144 |
| A | HIS210 |
| A | CYS141 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS141 |
| B | HIS144 |
| B | CYS212 |
| B | HOH419 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | CYS141 |
| C | HIS144 |
| C | CYS212 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | HIS144 |
| D | HIS210 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue ZN E 301 |
| Chain | Residue |
| E | CYS141 |
| E | HIS144 |
| E | CYS212 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue QBK E 302 |
| Chain | Residue |
| D | SER228 |
| D | ARG235 |
| D | ARG241 |
| E | ASP127 |
| E | THR240 |
| E | GLU243 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11087827","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17704208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
